Cancer has no borders. Neither do we.
年度報告2024
?2024
2 4 8 43 129 130 153 162 229 259 264 349 355
?
2024
Olivier Brandicourt
Margaret Han DuganMichael GollerAnthony C. HooperRanjeev KrishanaAlessandro RivaCorazon (Corsee) D. SandersShalini Sharp
Shalini Sharp
Olivier Brandicourt
Corazon (Corsee) D. SandersAnthony C. Hooper
Margaret Han DuganRanjeev Krishana
Anthony C. Hooper
Michael GollerAlessandro RivaShalini Sharp
Alessandro RivaMargaret Han DuganMichael GollerCorazon (Corsee) D. Sanders
* 2024122Thomas MalleyMalley
MalleyMalley
20241025Donald W. Glazer
1. 2024123
2. 2024927
3. 2024927202531
4. 202531
5. 2025116
6. 2024319
?2024
Anthony C. HooperOlivier Brandicourt
Margaret Han DuganRanjeev KrishanaCorazon (Corsee) D. Sanders
(FCG, HKFCG)Vistra Corporate Services (HK) Limited
Ernst & Young LLP
The offices of Mourant Governance Services (Cayman) Limited94 Solaris AvenueCamana BayGrand Cayman KY1-1108Cayman Islands
Mourant Ozannes
171712-1716
Mourant Governance Services (Cayman) Limited94 Solaris Avenue, Camana BayGrand Cayman KY1-1108Cayman Islands
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2021620212023
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2024
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20241231(i)11(ii)10013(iii)141.5
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20241231100
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202412317.20120241231100720
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112025
Olivier Brandicourt69Margaret Han Dugan68Michael Goller50Anthony C. Hooper70Ranjeev Krishana51Alessandro Riva64Corazon (Corsee) D. Sanders68Shalini Sharp50
5720101020052009BioDuro, LLCPharmaceutical ProductDevelopment Inc.20022004Galenea Corp.
19982002Telephia, Inc.2007(The Nielsen Company)19971998Genta Inc.
(McKinsey & Company)1990619961
?2024
62201622011
20032010202019972010Howard Hughes Medical Institute20012010
George L. MacGregor2004JoyantPharmaceuticals, Inc.219719847
1991520042013
?2024
Olivier Brandicourt6920241Brandicourt201911Blackstone Life SciencesBlackstone GroupBrandicourtAlnylam Pharmaceuticals, Inc.RNAi
Dewpoint Therapeutics, Inc.AvenCell Therapeutics, Inc.
CAR-TBrandicourt30
2015420198Sanofi S.A.Sanofi20131120153Bayer HealthCare AG20002013Pfizer Inc.
SanofiBrandicourt201920172019BrandicourtBrandicourtBrandicourt
Margaret Han Dugan6820222DuganSchrodinger,Inc.SDGR2018Dracen20DuganAmerican CyanamidDuganDugan
?2024
Michael Goller5020154GollerBaker Brothers Investments2005Baker BrothersGoller19992003JPMorgan Partners,LLC19971999Goller(MerrillLynch and Co.)GollerDBV Technologies SA
Replimune Group, Inc.REPL20172019Levo Therapeutics, Inc.Goller19975
20055
GollerAnthony C. Hooper7020201Hooper20201201892020120112018820102011HooperBristol Myers Squibb Company (BMS)20092010HooperBMS20042009HooperBMSHooperBMS
BMSHooperHooper19781988MBAHooperMannKind CorporationMNKDHooper
Ranjeev Krishana5120141020202Krishana2011Baker Bros. Advisors LPBaker Bros.Krishana(Pfizer, Inc.)
Krishana200320072008201120082010KrishanaKrishanaAccenture plcKrishanaImmunocore Holdings plc
IMCRKrishana1995520116Krishana
?
2024
Alessandro Riva642022220212023RivaIntimaBioscience, Inc.20192021
Ichnos Sciences
20172019Riva
Kite Pharma20052016Riva
GSKRivaBicycle Therapeutics plcBCYCCenturyTherapeutics, Inc.IPSC
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Farmitalia Carlo ErbaRh?ne-Poulenc RorerAventis(BCIRG)(CIRG)RivaRivaCorazon (Corsee) D. Sanders6820208Sanders(Bristol Myers Squibb Corporation)201911
20202Sanders20183201911
2017120183Juno Therapeutics
19942017SandersGenentechGenentech(Late StagePortfolio Committee)Genentech(Late Stage Clinical Operations)GenentechGenentechGenentech DATA
Sanders(Fred Hutchinson CancerResearch Center)(Board of Trustees)Legend Biotech CorporationLEGNAltruBio Inc.AbGenomicsUltragenyx Pharmaceutical Inc.RARESanders(Magna Cum Laude)Sanders
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2024
Shalini Sharp5020249SharpNeurocrine Biosciences, Inc.NBIXOrganon & CoOGN
Septerna, Inc.LEGN20125202010SharpUltragenyx Pharmaceuticals Inc.2003820125SharpAgenus, Inc.
2012520186SharpElanPharmaceuticalsMcKinsey & CompanySharp20213Mirati Therapeutics, Inc.20241201811202311
Sutro Biopharma, Inc.20181220226Precision BioSciences, Inc.20207Panacea Acquisition Corp.
20211Nuvation Bio20174Array Biopharma20196SharpSharp
532014106618(Hillhouse Capital)2005
1995720035
?2024
2025418
Aaron Rosenberg48
Chan Lee57
6320184202141
20184200920184201720184(Pfizer Essential Health)
2004200920012004199220082018(RDPAC)20152018
(NDPE)2017201720171993419901
?2024
Aaron Rosenberg4820247Rosenberg
2021Rosenberg20182021Rosenberg20152018120
2003Rosenberg
482021420115
2010Joyant Pharmaceuticals19962001Chan Lee5720227Lee2520162022Lee
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13.51(B)(1)
20241231
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Thomas Malley2024122Olivier Brandicourt202412320243
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2024123120241231270
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Olivier Brandicourt
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(1) 2024123Olivier Brandicourt
(2) 2024927Shalini Sharp* 2024122Thomas MalleyMalley
MalleyMalley
?2024
20241025Donald W. Glazer
2026202720252025Anthony C. HooperRanjeev KrishanaShalini SharpShalini Sharp20249
Shalini Sharp2025Shalini Sharp2027Shalini Sharp(i)20248203.09D(ii)
202412313.13
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20241231XV
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(14)
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Margaret Han Dugan164,307
(15)
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Michael Goller503,724
(16)
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(18)
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(19)
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2,527,017
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(4)980,928
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(5)
(6) Oyler Investment LLC
Oyler Investment LLC 99%
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(8)(9)
(10) (1)5,015,703(2)9,035,749
(3)225,179
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180,622(3) Hooper29,263
(18) (1) Krishana46,696(2)KrishanaKrishana
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(19) (1) Riva29,614(2)RivaRiva118,352
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(20) (1) Sanders29,900(2)SandersSanders
140,751(3) Sanders16,341
(21) (1)SharpSharp17,238
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(3)16,34120241231
(a)XV7
(b)352(c)
?2024
20241231
XV23
(1)Amgen Inc.246,269,42617.78%Julian C. Baker
(2)
125,377,5949.05%Felix J. Baker
(2)
125,377,5949.05%Baker Bros. Advisors (GP) LLC
(2)
124,921,9349.02%Baker Bros. Advisors LP
(2)
124,921,9349.02%Baker Brothers Life Sciences Capital, L.P.
(2)
114,632,5048.28%HHLR Advisors, Ltd.
(3)
111,597,4238.06%HHLR Fund, L.P.
(3)
111,597,4238.06%The Capital Group Companies, Inc.
(4)
96,385,8916.96%JPMorgan Chase & Co.
(5)
24,061,5671.74%21,150,519(S)1.53%(S)3,373,4180.24%
126,5200.01%
4,7580.0003%106,282,4197.67%
(S)
(1) 202412311,384,840,6872,527,017
(2) Julian C. BakerFelix J. BakerBaker Bros. Advisors (GP) LLCBaker Bros. Advisors (GP) LLC
Baker Bros. Advisors LPBBABBA667, L.P.Baker Brothers Life Sciences, L.P.Baker Brothers Life Sciences Capital, L.P.Baker Brothers Life Sciences, L.P.
BBAMichael GollerRanjeev Krishana
BBA
?
2024
Baker Brothers Life Sciences Capital, L.P.Baker Bros. Advisors (GP) LLCJulian C. BakerFelixJ. Baker202412112024129113,625,056Baker Brothers Life Sciences, L.P.Julian C. BakerFelix J. BakerBaker Bros. Advisors (GP) LLCBBA667, L.P.10,289,430BakerBrothers Life Sciences, L.P.113,625,056723,996BBABaker Brothers Life Sciences Capital, L.P.
Baker Brothers Life Sciences, L.P.113,625,056723,996BBAJulian C. BakerFelix J. Baker270,868FBB3 LLC144,517
(3) (i) 111,597,423HHLR Fund, L.P.YHG Investment, L.P.(ii) 13,447,603HillhouseBGN Holdings LimitedHHLR Advisors, Ltd.YHG Investment, L.P.HHLR Fund,L.P.Hillhouse Capital Management, Ltd.Hillhouse Fund II, L.P.Hillhouse Fund II, L.P.Hillhouse BGN Holdings LimitedHHLR Advisors, Ltd.
HHLR Fund, L.P.YHG Investment, L.P.111,597,423Hillhouse CapitalManagement, Ltd.Hillhouse BGN Holdings Limited13,447,603Hillhouse Fund II, L.P.Hillhouse BGN Holdings Limited13,447,603
(4) (i) 7,311,624Capital International, Inc.(ii) 1,052,088Capital International Limited
(iii) 2,096,140Capital International Sarl(iv) 83,338,123Capital Research andManagement Company(v) 227,090Capital Group Investment Management Private Limited
(vi) 2,360,826Capital Group Private Client Services, Inc.Capital Group International, Inc.Capital Research and Management CompanyCapitalInternational, Inc.Capital International LimitedCapital International SarlCapital Group InvestmentManagement Private LimitedCapital Group Private Client Services, Inc.Capital Group International,Inc.Capital Bank and Trust CompanyThe Capital Group Companies, Inc.Capital Research and Management CompanyCapital Group International, Inc.CapitalInternational, Inc.Capital International LimitedCapital International SarlCapital Group InvestmentManagement Private LimitedCapital Group Private Client Services, Inc.13,047,768Capital Research and Management CompanyThe Capital Group Companies Inc.The Capital Group Companies Inc.Capital Research and Management Company96,385,891
(5) JPMorgan Chase & Co.20241211JPMorgan Chase & Co.133,848,68221,150,519106,282,419523,9961,035,265
20241231
XV23
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2016(ii) 35,169,0942016(iii)20185,070,0002018
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20,409,697201620182016201820162018202465202412318,437
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20241231
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100.50500,000499,993
(8)
Thomas Malley*2016125
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1.85552,752552,747
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2015629
(3)
100.501111
2011520 2016 131
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* Thomas Malley2024122
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(5) 1310.9115.90
0.301.85
(6) Thomas Malley2024122Thomas Malley
20241232024122
(7) 1310.97
0.01
(8) 1314.62
0.50
2. 20162024652016
201618
2016
?2024
2016
2016
(i)(ii)(iii)(iv)(v)(vi)(vii)
202411201637,575,472202411202464
4,732,637201620246520162016
2024652024123154,141,25620168,43720241231202541883,064,17584,979,82920,401,26020,401,2602016
?2024
2024112016165,493,25520162024112024644,282,8892024652016
2016
20162024652024123120,751,666202412312025418233,278,768225,542,962202541816.07%2016
20162016121%
?2024
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(7) 12
?2024
2016(x)
(y)
2016
2016201620304132016520162016
20241231201620161,2042016201620162820241231
201620160.5
28.81
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20241161,516,76020162024123164,383,9262016
(1)(2)
2024
20241231
2016
1116(3)
2.792.842,047,500––––2,047,5002017
(3)
6.737.70935,000––––935,0002018
(3)
13.3713.04996,810––––996,8102018
(3)
12.7012.341,310,088––––1,310,0882019
(3)
9.259.232,193,282––––2,193,2822020
(3)
13.3313.421,821,976––––1,821,9762021
(3)
25.5426.53906,906––––906,9062022
(3)
11.7411.981,887,678––––1,887,6782023
(3)
16.0116.411,349,907––––1,349,9072024
(3)
11.9312.23–923,975–––923,9752016
1116
(3)
2.792.841,613,430––––1,613,4302017927
(3)
6.737.70750,000––––750,0002018
(3)
12.7012.34655,044––––655,0442019
(3)
9.259.23747,708––––747,7082020
(3)
13.3313.42560,599––––560,5992021
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?2024
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2024
202412312022
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11.7411.98471,913––––471,9132023
(3)
16.0116.41327,249––––327,2492024
(3)
11.9312.23–410,657–––410,657Anthony C. Hooper
2020
(5)
12.6212.2221,970––––21,9702020
(5)
13.3313.4245,383––––45,3832021
(5)
25.5426.5317,498––––17,4982022
(5)
11.7411.9834,645––––34,6452023
(5)
16.0116.4126,975––––26,9752024
(5)
11.9312.23–34,151–––34,151Olivier Brandicourt
2024
(5)
13.7312.74–27,794–––27,7942024
(5)
11.9312.23–34,151–––34,151Margaret Han Dugan
2022
(5)
16.4716.2222,581––––22,5812022
(5)
11.7411.9834,645––––34,6452023
(5)
16.0116.4126,975––––26,9752024
(5)
11.9312.23–34,151–––34,151Donald W. Glazer*
2017
(4)
2.842.83199,992––––199,9922018
(5)
15.7316.1517,442––––17,4422019
(5)
9.259.2364,610––––64,610
?2024
(1)(2)
2024
202412312020
(5)
13.3313.4245,383––––45,3832021
(5)
25.5425.6317,498––––17,4982022
(5)
11.7411.9834,645––––34,6452023
(5)
16.0116.4126,975––––26,9752024
(5)
11.9312.23–34,151–––34,151Michael Goller2017
(4)
2.842.83199,992––––199,9922018
(5)
15.7316.1517,442––––17,4422019
(5)
9.259.2364,610––––64,6102020
(5)
13.3313.4245,383––––45,3832021
(5)
25.5425.6317,498––––17,4982022
(5)
11.7411.9834,645––––34,6452023
(5)
16.0116.4126,975––––26,9752024
(5)
11.9312.23–34,151–––34,151Ranjeev Krishana
2017
(4)
2.842.83199,992––––199,9922018
(5)
15.7316.1517,442––––17,4422019
(5)
9.259.2364,610––––64,6102020
(5)
13.3313.4245,383––––45,3832021
(5)
25.5425.6317,498––––17,4982022
(5)
11.7411.9834,645––––34,645
?
2024
(1)(2)
2024
202412312023
(5)
16.0116.4126,975––––26,9752024
(5)
11.9312.23–34,151–––34,151
Thomas
Malley**
2017
(5)
(10)
2.9413.083.15169,988–169,988–––2018
(5)
(10)
15.7316.1517,442––––17,4422019
(5)
(10)
9.2513.099.2364,610–64,610–––2020
(5)
(10)
13.3313.4245,383––––45,3832021
(5)
(10)
25.5425.6317,498––––17,4982022
(5)
(10)
11.7411.9834,645––––34,6452023
(5)
(10)
16.0116.4126,975––––26,975Corazon D.Sanders
2020
(5)
18.5018.2627,482––––27,4822021
(5)
25.5425.6317,498––––17,4982022
(5)
11.7411.9834,645––––34,6452023
(5)
16.0116.4126,975––––26,9752024
(5)
11.9312.23–34,151–––34,151
–Alessandro
Riva
2022
(5)
16.4716.2222,581––––22,5812022
(5)
11.7411.9834,645––––34,6452023
(5)
16.0116.4126,975––––26,9752024
(5)
11.9312.23–34,151–––34,151
?2024
(1)(2)
2024
20241231Shalini Sharp2024930
(5)
16.8017.27–17,238–––17,2382017419
(4)
2.842.83199,992––––199,992201866
(5)
15.7316.1517,442––––17,442201965
(5)
9.259.2364,610––––64,6102020617
(5)
13.3313.4245,383––––45,3832021616
(5)
25.5425.6317,498––––17,4982022622
(5)
11.7411.9834,645––––34,6452023615
(5)
16.0116.4126,975––––26,975202465
(5)
11.9312.23–34,151–––34,151
–2018430
(6)
13.3713.04766,599––––766,599201965
(3)
9.259.23797,550––––797,5502020617
(3)
13.4213.33756,821––––756,8212021616
(3)
25.5425.63483,678––––483,6782022622
(3)
11.7411.981,061,814––––1,061,8142023615
(3)
16.0116.41760,851––––760,851202465
(3)
11.9312.23–477,386–––477,386
?2024
(1)(2)
2024
20241231***2020630
(3)
(11)
14.5514.66104,754––––104,7542021616
(3)
(11)
25.5426.53177,853––––177,8532022
(3)
(11)
11.7411.98589,888––49,296–540,5922023
(3)
(11)
16.0116.41409,058––136,500–272,5582024
(3)
(11)
11.9312.23–256,659–256,659––Aaron
Rosenberg
2024
(3)
14.0814.06–220,987–––220,9872018
(3)
12.7012.34364,208––––364,2082019
(3)
9.259.23558,285––––558,2852020
(3)
13.3313.42525,564––––525,5642021
(3)
25.5426.53332,527––––332,5272022
(3)
11.7411.98707,876––––707,8762023
(3)
16.0116.41507,234––––507,2342024
(3)
11.9312.23–318,253–––318,253Chan Lee
2022
(3)
2.262.27188,929––––188,9292023
(3)
16.0116.41248,950––––248,9502024
(3)
11.9312.23–184,795–––184,795
?2024
(1)(2)
2024
202412312016
(3)
2.272.29200,000–––200,0002024
(12)
13.7312.74–16,380––16,3802016
(3)
2.2715.492.292,754,293–616,642–72,137,6442016
(3)
2.1315.122.1068,827–49,218–1219,5972016
(6)
2.1314.982.10732,232–114,140–27618,0652016
(3)
2.112.023––3––2016
1012
(3)
2.482.426–––62016
1017
(3)
2.4212.062.5556,212–56,212––2016
1130
(3)
2.432.441,274–––1,2742016
(3)
2.072.0934,099–––34,0992017
(3)
2.342.397,800–––7,8002017
(6)
2.5114.882.5335,763–27,521––8,2422017
(3)
2.682.77144,989–––144,9892017
(3)
2.762.7632,201–––32,2012017
(3)
2.7712.392.779,243–7,800–1,4432017
(3)
3.083.02116,701–––116,7012017
(3)
3.0415.003.0469,368–42,458–26,9102017
(6)
2.8116.082.8228,704–7,904–20,800
?2024
(1)(2)
2024
202412312017
(6)
3.1315.413.12100,854–1,950–98,9042017
(3)
3.123.1211,999–––11,9992017
(6)
2.8314.452.94147,914–109,525–38,3892017
(3)
2.9911.853.0012,727–12,727––2017
(3)
3.0415.203.05407,160–64,480–342,6802017
(6)
3.0515.063.042,747,446–495,378––2,252,0682017
(3)
3.5015.763.492,132,624–117,208–2,015,4162017
(3)
3.503.4533,657–––33,6572017
(3)
5.4013.005.451,300–1,300––2017
(6)
5.6715.054.19234,130–61,282–172,8482017
(3)
5.5813.085.4260,996–60,996––2017
(6)
5.5815.455.42285,519–62,998–222,5212017
(3)
5.4215.855.5839,000–39,000––2017
(3)
5.455.5119,994–––19,9942017
(3)
5.5615.955.9539,000–39,000––2017
(3)
5.295.2824,167–––24,167
?2024
(1)(2)
2024
2024123120178
(6)
5.3015.525.30168,168–29,744–138,424201795(3)
5.785.6835,009–––35,00920179
(3)
6.226.3722,269–––22,26920179
(3)
6.5512.616.56121,992–70,499–51,49320179
(3)
7.4913.917.9637,492–37,492––201711
(3)
7.1012.166.84199,056–108,862–90,194201711
(3)
6.386.1510,764–––10,764201815
(3)
7.727.5819,071–––19,07120181
(3)
9.5210.4480,017–––80,01720184
(3)
13.3713.046,149–––6,149201866(5)
15.7316.1517,442–––17,44220186
(3)
12.7014.4412.34641,433–128,726–512,70720186
(3)
11.9011.8312,103–––12,10320188
(7)
13.6713.666,708–––6,70820189
(3)
13.2813.2565,433–––65,43320189
(8)
13.2813.2539,260–––39,260201811
(3)
11.0711.7911,028–––11,028201812
(3)
10.5314.0210.79107,016–7,800–99,216
?
2024
(1)(2)
2024
2024123120181231
(8)
10.5313.8510.7912,194–12,194––2019
(3)
9.6210.4438,649–––38,6492019
(3)
11.6812.4111.5178,494–78,494––2019
(3)
9.3310.3244,213–––44,2132019
(3)
9.2514.189.231,865,240–349,687–1,515,5532019
(5)
9.259.23129,220–––129,2202019
(3)
11.1413.7511.0679,300–4,641–74,6592020
(3)
9.659.67294,775–––294,7752020
(3)
13.3314.6313.421,182,181–83,0313,09436,4261,059,6302020
(5)
13.3313.4290,766–––90,76620206
(3)
14.5514.66212,771–––196,40416,3672020
(3)
17.2416.9940,248–––40,2482020
(3)
21.6522.038,021–––8,0212020
(3)
23.0823.07162,994––––162,9942020
1130
(3)
21.9920.9915,756––3,04212,714–2021
(3)
27.4628.8155,263––1,0533,95250,2582021
(3)
25.3625.816,331––1,6384,693–20213
(3)
25.6126.78148,824––3,90024,700120,224
?2024
(1)(2)
2024
20241231
2021
(3)
24.1524.7884,240–––84,2402021
(3)
27.0027.58121,485–––121,4852021
(3)
25.5426.531,608,737––37,089177,7621,393,8862021
(5)
25.5426.5317,498––––17,4982021
(3)
27.4827.2848,113––5,0059,03534,0732021
(3)
25.8425.6168,341––––68,3412021
(3)
23.2223.72153,322––7,163126,25619,9032021
(3)
27.8128.7355,458––2,483–52,9752021
(3)
28.3828.0823,231––3,9527,20212,0772021
1130
(3)
26.4026.8564,649––5,6555,92853,0662021
1231
(3)
21.0320.8426,637––4,8365,21316,5882022
(3)
17.2718.61371,059––3,627367,4322022
(3)
16.4718.8116.22151,580––––151,5802022
(3)
15.8515.46135,694–––135,6942022
(3)
12.2715.3112.5063,349–8,125–55,2242022
(3)
10.3015.3110.56123,604–4,589–119,0152022
(3)
11.7414.3711.985,102,089–530,439332,293117,3124,122,0452022
(9)
11.7411.9811,804–––11,804
?2024
(1)(2)
2024
20241231
2022
(3)
12.4813.8812.8174,217–1,4046,13666,6772022
(3)
12.7313.3222,009–––22,0092022
(3)
10.4810.5863,024–––63,0242022
1110
(3)
13.5614.5246,176–––46,176202211
(3)
13.8414.7417,745–––17,7452022
1230
(3)
17.2217.267,592––4,2903,302–2023
(3)
20.5220.6429,471––4,5501,50823,4132023
(3)
16.6217.2861,724–––61,7242023
(3)
16.6717.8116.9951,844–3,23713,1042,32733,1762023
(3)
20.0520.0618,395––3,9651,59912,8312023
(3)
17.5617.9819,188–––19,1882023
(3)
16.0117.8516.415,183,529–97,136420,83613,2214,652,3362023
(3)
13.7413.8230,277–––30,2772023
(3)
14.6016.0866,729–––66,7292023
(3)
16.2515.9754,314––16,14638,1682023
(3)
14.1715.8614.51192,686–4,64126,234161,8112023
1113
(3)
15.3215.3024,297–––24,2972023
1130(3)
14.0914.3832,968––22,38610,582
?2024
(1)(2)
2024
2024123120231229
(3)
13.8113.8750,271––11,07639,1952024
(3)
12.4812.40–49,673–12,18137,4922024
(3)
13.7312.74–12,012––12,0122024
(3)
11.9312.03–74,464––74,4642024
(3)
12.9712.59–155,792––155,7922024
(3)
11.8711.81–145,340––145,3402024
(3)
11.9312.23–5,011,318–382,2654,629,0532024
(3)
11.2011.67–22,880––22,8802024
(3)
14.0814.06–75,868––75,8682024
(3)
15.2415.26–48,802––48,8022024
(3)
16.8017.27–278,031––278,0312024
1114
(3)
15.0315.48–47,164––47,1642024
1129
(3)
15.8616.54–67,951––67,9512024
1231
(3)
14.1414.21–29,523––29,523
61,516,7609,180,3013,783,0781,780,457749,60064,383,926
?2024
* Donald W. Glazer20241025** Thomas Malley2024122*** 2024719
(1) 13
(2) 13
(3) 25%
75%25%36(4)(5)
Thomas Malley2024122Thomas Malley20241232023615Thomas Malley
20241232024630
(6) 20%80%20%48
(7) 48(8)
(9) 50%50%50%12
?2024
(10) Thomas Malley2024122Thomas Malley
Thomas Malley
(11) 2024717
(12)
?2024
20162016
(3)
923,975202465(1)12.23–11.935,999,924410,657202465(1)12.23–11.932,666,642Anthony C. Hooper34,151202465(2)12.23–11.93199,995Olivier Brandicourt27,7942024229(2)12.74–13.73158,862
34,151202465(2)12.23–11.93199,995Margaret Han Dugan34,151202465(2)12.23–11.93199,995Donald W. Glazer*34,151202465(2)12.23–11.93199,995Michael Goller34,151202465(2)12.23–11.93199,995Ranjeev Krishana34,151202465(2)12.23–11.93199,995Corazon D. Sanders34,151202465(2)12.23–11.93199,995Alessandro Riva34,151202465(2)12.23–11.93199,995Shalini Sharp17,2382024930(2)17.27–16.80140,779
34,151202465(2)12.23–11.93199,995
477,386202465(1)12.23–11.933,099,954**256,659202465(1)12.23–11.931,666,641Aaron Rosenberg220,987202489(1)14.06–14.081,666,662
318,253202465(1)12.23–11.932,066,608Chan Lee184,795202465(1)12.23–11.931,199,985
6,018,8182024124
20241231
(1)11.67-
17.27
–11.20-
16.80
40,186,26216,3802024229(4)12.74–13.7399,9529,180,30160,752,226
?2024
* Donald W. Glazer20241025** 2024719
(1) 25%
75%25%36
(2)
(3)
(4) 100%
20162016202412312016201617,828
3220162016
201792620241231
?
2024
20241166,401,02320162016
2024123183,668,5852,162,08220162016
2024
20241231
2024(1)
2021616(6)25.5473,138–36,556–36,58212.51
2022622(6)11.74250,510–83,499–167,01112.012023615(6)16.01355,641–88,907–266,73412.51202465(6)11.93–490,464––490,464–202465(9)11.93–490,464
(10)
––490,464–2021616(6)25.5419,500–9,750–9,75012.512022622(6)11.7462,634–20,865–41,76912.012023615(6)16.0186,216–21,554–64,66212.51202465(6)11.93–108,992––108,992–Anthony C. Hooper2022622(7)11.7416,692–16,692––14.14
2023615(7)16.0112,922–––12,922–202465(7)11.93–16,341––16,341–Olivier Brandicourt202465(7)11.93–16,341––16,341–Margaret Han Dugan2023615(7)16.0112,922–12,922––11.93
202465(7)11.93–16,341––16,341–Donald W. Glazer*2022622(7)11.7416,692–16,692––14.14
2023615(7)16.0112,922–––12,922–
202465(7)11.93–16,341––16,341–
?2024
2024
20241231
2024(1)Michael Goller2023615(7)16.0112,922–12,922––11.93
202465(7)11.93–16,341––16,341–Ranjeev Krishana2023615(7)16.0112,922–12,922––11.93
202465(7)11.93–16,341––16,341–Thomas Malley**2023615(7)16.0112,922––12,922––Corazon D. Sanders2023615(7)16.0112,922–12,922–––
202465(7)11.93–16,341––16,341–Alessandro Riva2023615(7)16.0112,922–12,922–––
202465(7)11.93–16,341––16,341–Shalini Sharp2024930(7)16.80–8,151––8,151–
2023615(7)16.0112,922–12,922–––
202465(7)11.93–16,341––16,341–
?
2024
2024
20241231
2024(1)
2020617(6)13.3333,566–33,566––12.012021616(6)25.5439,000–19,500–19,50012.012022622(6)11.74140,907–46,969–93,93812.512023615(6)16.01200,447–50,102–150,34512.01202465(6)11.93–253,409––253,409–202465(11)11.93–253,409
(10)
––253,409–***2020630(6)14.5513,819–13,819––11.20
2021616(6)25.5414,352–14,352––14.032022228(6)16.4746,319–46,319––14.552022622(6)11.7478,286–52,18226,104–14.032023615(6)16.01107,770–53,87253,898–14.03202465(6)11.93–136,240–136,240––202465(11)11.93–136,240
(10)
–136,240––Aaron Rosenberg202465(6)14.08–118,547––118,547–
202465(11)14.08–118,547
(10)
––118,547–2020617(6)13.3323,309–23,309––12.512021616(6)25.5426,819–13,403–13,41612.512022622(6)11.7493,951–31,304–62,64712.012023615(6)16.01133,627–33,397–100,23012.51202465(6)11.93–168,935––168,935–202465(11)11.93–168,935
(10)
––168,935–Chan Lee
2022729(6)13.4587,009–29,003–58,00612.502023615(6)16.0165,585–16,393–49,19212.51202465(6)11.93–98,085––98,085–202465(11)11.93–98,085
(10)
––98,085–
?2024
2024
20241231
2024(1)
201813120211231
(6)18.558,302,047–5,194,956735,2412,371,850(2)20221120221231
(6)12.2823,899,564–7,592,4812,314,78013,992,303(3)20231120231229
(6)15.6232,088,680–7,600,0473,260,85521,227,778(4)20241120241231
(6)12.21–45,741,4755,8112,228,56443,507,100(5)202465(11)11.93–1,140,269
(10)
–107,6271,032,642–20231120231231
(8)13.818,645–8,645––20241120241231
(12)13.73–16,276––16,276
66,401,02349,693,59221,251,4779,012,47185,830,667
?2024
* Donald W. Glazer20241025** Thomas Malley2024122*** 2024719
(1) 13
(2) 1310.9717.27
(3) 1310.9717.27
(4) 1310.97
16.80
(5) 1310.97
14.75
(6) 25%
(7)
Thomas Malley2024122Thomas Malley(8)
?
2024
(9)
(10) 100%
0200%(11)(12)
?2024
(3)
490,464202465(1)–11.935,999,884490,464202465(5)(6)11.935,999,884108,992202465(1)–11.931,333,308Anthony C. Hooper16,341202465(2)–11.93199,901Olivier Brandicourt16,341202465(2)–11.93199,901Margaret Han Dugan16,341202465(2)–11.93199,901Donald W. Glazer*16,341202465(2)–11.93199,901Michael Goller16,341202465(2)–11.93199,901Ranjeev Krishana16,341202465(2)–11.93199,901Corazon D. Sanders16,341202465(2)–11.93199,901Alessandro Riva16,341202465(2)–11.93199,901Shalini Sharp8,1512024930(2)–16.80140,768
16,341202465(2)–11.93199,901253,409202465(1)–11.933,099,972253,409202465(7)(6)11.933,099,972**136,240202465(1)–11.931,666,634
136,240202465(7)(6)11.931,666,634Chan Lee98,085202465(1)–11.931,199,881
98,085202465(7)(6)11.931,199,881Aaron Rosenberg118,547202489(1)–14.081,666,588
118,547202489(7)(6)14.081,666,588168,935202465(1)–11.932,066,595168,935202465(7)(6)11.932,066,595
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20241231
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2024
* Donald W. Glazer20241025** 2024719
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2024
20241120181,941,075202411
2023912024112024641,021,397201820246520182018
202465202412311,035,99620182024123120254184,953,6823,998,2862018
2024123120241231202493
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20182018
202391
202391
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3. 20239111,816,543
1,021,397
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202431
202431
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202431610.7910,623.3010,520.03
10.79
202431610.7911,338,41211,167,637.74
10.79
1,035,02111,178,157.76
1. 20243112.7499.71
13,150,774102,939,1302024312018
2018
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202483010.791,035,021202483015.27119.10
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2024
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20241231
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2024
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202531Shalini SharpAnthony C. Hooper
20241231
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2025
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2024
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Ranjeev Krishana
?2024
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2024
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2024123158.2%41.7%
202412
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202420231231Ernst& Young LLP
202420238,0537,057–648,0537,12110-Q
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Olivier BrandicourtMargaret Han DuganDonald W.GlazerMichael GollerAnthony C. HooperRanjeev KrishanaAlessandro RivaCorazon (Corsee) D. Sanders1,257
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2024416202461220244262024123114A.71
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Committee of Sponsoring Organizations of the Treadway Commission2013
?2024
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20241231
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Chan Lee202412313.29
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2024
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123120242023
580,000
92027611116,440120,00014,089100,000350,000
9202912028,61162,8578,85662,857378,000
9202911838,14859,4755,63640,000 480,000
10203272841,38410,100––380,00015380,0002,773,723300,0002,129,321150,0001202512166.8%150,0001,094,891150,0001,064,660675,000
3642025327692,475675,000––400,000
12025653.0%54,800400,00056,356400,000340,000
1202555746,580340,00047,903340,000 200,000
120245292.8%––28,177200,000700,000
1202511242.9%93,091679,49249,312350,000 200,000
120245243.2%––28,037199,000
851,5296,215,538688,3664,885,838580,000
92027611141,100300,00059,174420,000350,000
92029120227,987204,28637,638267,143378,000
92029118333,020241,02542,337300,500 480,000
102032728464,377469,90058,469415,000
166,4841,215,211197,6181,402,643
?2024
14.
1. 20241231
4.2%2024123113,739,000100,000,000
2. 20241231
3.7%202412318,730,00062,857,000
3. 20241231
3.8%202412315,562,00040,000,000
4. 20241231
3.7%202412319,053,00065,000,000
5. (SOFR)20241231
6.2%80,000,0002025127300,000,00020251217
6. 20241231
2.6%
7. 202412314.4%
20241231
?2024
14.
20241231
20251231851,5292026123146,2072027123146,2072028123125,6572029123119,657
28,7561,018,013
20242023123146,894,00020,800,00032,158,00016,571,00020242023123119,723,0003,484,00015.
???????
?202420231231
1231202420234,786,7442,718,969(1,007,198)(529,117)3,779,5462,189,852
?2024
15.
202420231231
123120242023
?
2,644,2261,290,396?
620,836536,620
?
224,40392,828
?
74,33154,342?
66,17139,799?
53,50956,547?
36,02876,018
60,04243,3023,779,5462,189,852202420231231
2022123141,8178,58050,397 275,031254,086529,117 (176,912)(232,231)(409,143)20231231139,93630,435170,371 491,756515,4421,007,198 (396,092)(495,178)(891,270)20241231235,60050,699286,299
?2024
16.
123120242023594,089379,9209166,93880,436
1,953,2951,778,594826,57525,978104,8247,239
8,0537,121 1,305,1471,120,403 18441,793367,588 74,09862,092
1,821,0381,550,083
15,98664,7606(1,034)1,861
4,0662,964(69,641)(78,373)
202420231231779,306,000699,289,000
?2024
17.
123120242023 (644,786)(881,708) 1,368,746,7931,357,034,547
(0.47)(0.65)202420231231
202420231231
?2024
18.
2016201612016
20162016265,029,5952016
201120112016
201120241231201120165,166,9002016201711
(i)(5%)(ii)
20181129,603,6162016201882016201812201638,553,159202062016
57,200,0002030413201620241231201683,064,175
20162016
201666,300,00020223315%202262220246201692,820,000
?2024
18.2018201862018201812,000,000
5635(c)(4)5635(c)(4)20182018
201620188
201820162018202262220182018620183,500,000
201882018123,855,3157,355,315202465,070,00012,425,3156
15%10%
?2024
18.
2018
20248311,035,996165.2012.69140.2710.7811,17820242291,021,397165.6512.74140.8010.8311,0632023831794,144207.5515.97176.4213.5710,7772023228930,582171.1013.16145.4411.1910,4142022831861,315171.6613.20145.9111.229,6672022228667,160210.5216.19178.9413.769,183
202412314,953,682
?2024
18.
201120162018
2022123176,526,8537.85 9,817,92516.378.14 (6,974,331)4.5492,051 (1,225,334)17.60
2023123178,145,1139.06 9,180,30112.536.62 (6,812,624)3.8769,946 (2,530,134)15.87
2024123177,982,6569.704.83429,581
2024123160,173,2808.423.7406,868
2024123175,311,2509.554.7426,174
2024123115,137,97082,424,000
2.4
?2024
18.
20242023123168,420,00061,121,000
123120242023
5.72~9.197.26~10.72
3.8% ~ 4.6%3.4% ~ 4.6%
2.82.857% ~ 58%58% ~ 60%
0%0%1010
?
2024
18.
20162018
2022123155,397,17314.87 34,573,99415.57 (17,862,598)14.71 (5,707,546)15.47
2023123166,401,02315.22 49,693,59212.53 (21,251,477)15.53 (9,012,471)14.46
2024123185,830,66713.67
2024123172,956,06713.67
20241231801,403,000
2.7
202420231231
123120242023186,113163,550255,680204,038441,793367,588
?2024
19.
20221231(62,523)(9,011)(5,883)(77,417)
(25,464)9,046(6,422)(22,840)
––811811(25,464)9,046(5,611)(22,029)
20231231(87,987)35(11,494)(99,446)
(47,565)(35)(2,753)(50,353)
––811811(47,565)(35)(1,942)(49,542)20241231(135,552)–(13,436)(148,988)
?
2024
20.
202420231231BMS202381BMS-Celgene
ABRAXANE
?20172018BMS-Celgene
201723,273,10820231231
??20252
2023815362,917,000
20231231
21.
?2024
21.
10%50%
202420231231
10%
2024202312311,709,961,0002,114,277,00022.
202420231231101,779,00094,358,000401(k)401(k)401(k)
401(k)20246%202420231231
401(k)20,839,00015,316,000
?2024
22.
2024202312313,825,0002,710,000
20242023123180,199,00070,600,00063,794,00055,605,00020253,922,000
1020241231
20251231692202612316042027123199420281231593202912311,922
8,65713,462
?2024
23.
20241231131,944,00032,538,000
99,406,000
2024123148,347,000
1,250,000,00020241231335,261,000
15,053,000202412317,404,000
(CRO)
?2024
24.
383(1)(a)(b)(c)(f)2202420231231
123120242023888856 1,2971,275 1,5401,132 *19,54817,981
22,38520,38823,27321,244* 2425
202420231231
?
2024
24.
(a)
20242023123120241231
Olivier Brandicourt
85––354–439Shalini Sharp
21––88–109Donald W. Glazer
69––614–683Michael Goller85––410–495Anthony C. Hooper130––410–540Ranjeev Krishana90––410–500Thomas Malley
5––14–19Corazon (Corsee)
D. Sanders103––410–513
90––410–500Margaret Han Dugan115––410–525Alessandro Riva95––410–505
888––3,940–4,828
1.
Olivier Brandicourt2024123
2.
Shalini Sharp2024927
3. Donald W. Glazer20241025
4.
Thomas Malley2024122
?2024
24.(a)
20231231
Thomas Malley101––405–506Donald W. Glazer81––405–486Michael Goller82––405–487Ranjeev Krishana87––405–492
87––405–492Corazon (Corsee)
D. Sanders102––405–507Alessandro Riva92––405–497Margaret Han Dugan111––405–516Anthony C. Hooper
113––405–518856––3,645–4,501
1.
Anthony C. Hooper20234172023416
Anthony C. Hooper2023416Anthony C. Hooper
?2024
24.(b)
202420231231
202420231231
123120242023–– 1,2971,275 1,5401,132 15,61014,336
18,44716,743202420231231
202420231231
20241231
100–1503,948–4,198
?2024
24.(b)
20231231
267–1503,854–4,271
25.
202420231231
20242023
123120242023
3,6012,2231,3441,64420,26718,874
211725,23322,758
?2024
25.
2024202335,000,00140,000,000–150,000,00155,000,0001160,000,00165,000,0001–80,000,00185,000,0001–90,000,00195,000,000–1
202420231231
26.
202420231231(a) 20241231
(i)100,0002023100,000(ii)150,0002023150,000(iii)410,6572023327,2492,667,00020232,667,000(iv) 108,992202386,216
1,333,00020231,333,000(v)20231231
(HSR)167,000(b)
12312024202310,2348,120513342,57538,15752,86046,31014A
?2024
27.
1231202420231,957,4981,128,2191,950,530945,5516,968182,6681,411,3071,101,9511,390,6991,093,09120,6088,860362,626202,014359,507122,2283,11979,78678,81026,59578,81028,982–(2,387)3,810,2412,458,779
?
2024
28.
20241231
(i)(iii)(1,953,295)(21,357)1,338(1,973,314)(1,831,056)(17,535)1,814(1,846,777)47,836–(2,677)45,159(533,001)(38,892)475(571,418)(111,785)(1,954)–(113,739)(644,786)(40,846)475(685,157)
20231231
(i)(iii)(1,778,594)(31,745)1,344(1,808,995)(1,508,001)(21,942)1,659(1,528,284)
74,009–(3,082)70,927(825,836)(53,687)(79)(879,602)
(55,872)(15,000)–(70,872)(881,708)(68,687)(79)(950,474)
?
2024
28.
20241231
(i)(ii)(iii)139,309––(1,909)137,4005,920,910––(1,909)5,919,00112,087,90840,846––12,713,377
276,729*307,894*–(8,606,836)(40,846)–475(9,234,214)
(276,729)*(307,894)*(2,384)*3,332,222––(1,909)3,330,313
20231231
(i)(ii)(iii)95,207––(2,384)92,8235,805,275––(2,384)5,802,89111,598,68868,687––12,183,311
208,042*307,894*–(7,962,050)(68,687)–(79)(8,549,057)
(208,042)*(307,894)*(2,305)*3,537,327––(2,384)3,534,943
*
?
2024
28.
(i)
2024123138,892,000202353,687,000
(ii)
20162307,894,000
307,894,000
?2024
28.
(iii)
?2024
29.
123120242023
400,135723,964 249,016785,471
649,1511,509,435 1,731,2662,030,249 2,081,3351,207,352 114,72869,361
4,576,4804,816,397
424,111197,289 –362,917 762,146547,215
1,186,2571,107,421 58,000171,649
1,244,2571,279,070
3,332,2233,537,327
4,576,4804,816,397
?2024
29.
202212311,356,140,18013511,540,979(77,417)(7,080,342)4,383,355
84,227––––– 26,561,925253,006––53,008
(23,273,108)(2)(362,915)––(362,917)
––367,618––367,618–––(22,029)–(22,029)––––(881,708)(881,708)
202312311,359,513,22413511,598,688(99,446)(7,962,050)3,537,327
(2,258,161)––––– 30,112,641345,550––45,553
––2,052––2,052––441,618––441,618–––(49,542)–(49,542)––––(644,786)(644,786)202412311,387,367,70413812,087,908(148,988)(8,606,836)3,332,222
?2024
30.
2024123120231231
31.
2025327
?2024
2011201141520154172011201620181272016
20224
201820182021616
202191
ADS
20162024652016
20244
2018
2024652018
20244
198747
20191031202012
20191031
?2024
2023615
20101028
2017125201733BeiGene Switzerland GmbH201791BLABMSBMS-CelgeneCelgene Switzerland LLC
Celgene Kappa Holdings LLCCelgene Holdings EastCorporation
CMO
?2024
C1 CRO
(i)(ii)(iii)
Ernst & Young AG
EMA(European Medicines Agency)
FDA(U.S. Food and Drug Administration)
(General Data Protection Regulation)(EU)2016/679
?
2024
GEMC3
NMPA(National Medical Products Administration)
Novartis Pharma AG NRDL
?2024
2018730
201620241231
20162016
sNDA
?2024
GAAPGAAP
?2024
ADCBRAFB-raf BTK
BcHLCLL
FcγFcγFL
MCLMZLNMENSCLC
?2024
PARPADP
DNADNAPD-11Tpro-B
PD-L1PD-L2PD-1T
SLLTTT
BUCWM