2022中期報告
?2022
2 4 8 37 67 68 69 71 72 74 122 127
?2022
Anthony C. Hooper
Margaret Han Dugan
Donald W. GlazerMichael GollerRanjeev KrishanaThomas MalleyAlessandro Riva
Corazon (Corsee) D. Sanders
Thomas MalleyAnthony C. HooperCorazon (Corsee) D. Sanders
Margaret Han Dugan
Ranjeev Krishana
Donald W. GlazerMichael GollerAnthony C. HooperAlessandro Riva
Corazon (Corsee) D. SandersMargaret Han Dugan
Michael GollerThomas MalleyAlessandro Riva
Anthony C. HooperMargaret Han Dugan
Ranjeev KrishanaCorazon (Corsee) D. Sanders* 2022131
2022622
1. 202221
2. 2022225
3. 2022913
?2022
(FCG, HKFCG)Vistra Corporate Services (HK) Limited
Ernst & Young LLP
Mourant Governance Services (Cayman) Limited94 Solaris AvenueCamana BayGrand Cayman KY1-1108Cayman Islands
Mourant Ozannes
171712-1716
Mourant Governance Services (Cayman) Limited94 Solaris Avenue, Camana BayGrand Cayman KY1-1108Cayman Islands
06160
www.beigene.com
?
2022
???????
?2022
????????????
?2022
?
??? /
? 10-K?
20211216
2024
?? 20211231
?2022
?2022
?(BTK)
?
PD-1?
PARP1PARP2
???
Novartis Pharma AG
2,5004080
316,000
CMO201029
8,600
?2022
2022920(NICE)
?
(BR)(WM)2022919(EMA)(CHMP)
??
CD20(MZL)20229102022(European Society for Medical Oncology,ESMO)PD-1
?
2022823NMPA
?(ESCC)(sBLA)2022893RATIONALE 301
(HCC)(OS)
2022714FDA
?
ESCC(2L)(BLA)FDA
BLAFDA20226302022(ESMO)RATIONALE 306RATIONALE 3063
?ESCC2022621NMPA
?
PD-L1(G/GEJ)sBLA2022613
?(MCL)NewBridge Pharmaceuticals(MENA)
?
MENA
?2022
2022613
?
(CLL)(SLL)(sNDA)FDA(PDUFA)2023120FDAPDUFA
sNDA3ALPINE
(IRC)CLLSLL
?
(ORR)20224112022610NMPA
?
(NPC)
1. 800
???
ociperlimabTIGITBGB-11417Bcl-2
2022BGB-A445OX40surzebiclimabTIM3BGB-10188PI3KδBGB-15025HPK-1BGB-16673BTKCDACBGB-23330TYK2BGB-24714SMAC
?2022
2.
2,500CRO
3.
3,100
4.
?
??
?WM
?
5.
?2022
20211(1)
(2)
?
2022
202112
TIGIT
?????
(1)(2)
(3)
?2022
?
???????
?
?
BTK?
?
PD-1? TIGIT?
?
PARP1PARP2? BGB-150251(HPK1)
?2022
? BGB-11417Bcl-2? BGB-A445OX40? BGB-16673BTKCDAC? BGB-A425TIM-3? BGB-10188PI3Kδ? BGB-233392(TYK2)? LBL-007LAG-3
?? SitravatinibMirati Therapeutics, IncMirati? ZW25(Zanidatamab)ZW49Zymeworks IncZymeworksHER2?
?(BAT1706)
?
?2022
???????????
?2022
ADS
202112
?2022
20222021630
20222021%
566,084244,741321,343131.3% 82,114511,123(429,009)(83.9)% 648,198755,864(107,666)(14.2)% 136,41068,94867,46297.8% 768,122676,81791,30513.5% 625,976414,395211,58151.1% 37637510.3% 1,530,8841,160,535370,34931.9%
(882,686)(404,671)(478,015)118.1% 21,502(9,045)30,547(337.7)% (117,650)(4,990)(112,660)2,257.7%
(978,834)(418,706)(560,128)133.8%
26,889(4,860)31,749(653.3)%(1,005,723)(413,846)(591,877)143.0%
?2022
20212022630
202263020216307.559
6.48214.2%6.50
20222021630
20222021%566,084244,741321,343131.3% –484,646(484,646)(100.0)% 24,24026,477(2,237)(8.4)% 52,497–52,497 5,377–5,377
82,114511,123(429,009)(83.9)%648,198755,864(107,666)(14.2)%
20222021%?
233,07264,513168,559261.3%?
192,522123,75868,76455.6%?
41,57626,77514,80155.3%?
29,00817,79211,21663.0%?
21,396–21,396?
19,798–19,798
?
8,9466,9611,98528.5%
?
8,405–8,405?
4,5772,2212,356106.1%
6,7842,7214,063149.3%566,084244,741321,343131.3%
?2022
2022630131.3%5.6612.447
?????
2021820221
?
2022120222022630??
2022630
?
2.331261.3%20226
?
1.5632,600500.5%
2022630
?
7,02082.7%(CLL)(SLL)2022630
?
1.9251.238
55.6%2022630
????
20213120212,8102021
???20226308,21020226302,420
5,25054020216305.111
4.84620216302,6503
20216306,89020226301.364
????
20218
??
20221
?
2022
20226304.29720216301.758
71.8%
202263075.9%
?????
2022120226302021630
20216306.7689,13013.5%20226
307.68120222021630
20222021%
232,009219,43312,5765.7% –53,500(53,500)(100.0)%
46,78955,330(8,541)(15.4)%278,798328,263(49,465)(15.1)%489,324348,554140,77040.4%768,122676,81791,30513.5%
20226309,2404,680
4,560
?2022
20226305,350
1.40840.4%4.893
? 6,500? 4,320? 2,570? 1,590
? 910
20216304.1442.11651.1%20226306.260? 1.174?
3,710
?2022
?3,670? 2,030
20216309003,050
337.7%20226302,1502021
20216305002022630
1.177
Leap Therapeutics
20226302,69020216304902022630
2021630
2022630(1)21.0
(2)237.035.0(3)
37.5
?2022
20211231483.164.3%2022630172.3
3.0
20211231242.68.1%2022630262.2
20222021630123172,47487,23959,29178,53818,62758,57917,40912,010
2,6115,0528,4621,695
28,50927,060207,383270,173
20211231587.67.7%2022630633.1
?2022
202263020211231234.4262.4
2022202163012313229,217257,977361,7253,210613,1371,1101276103
234,355262,400
202263020211231
202220216301231124,565139,966151,321213,922
55,36671,560
23,52545,661
71,51259,639
27,89427,307454,183558,05520211231558.118.6%2022630
454.22022630
?2022
202263020211231
2022202163012314,535,4094,382,8871,172,5542,241,962565,936629,678(BMS)
20226301020216304.138202263060
201792022630
20211
6.5202112TIGIT202213
?2022
20222021630
202220214,382,8871,390,005 (616,522)(295,171) 869,103543,544 (28,847)143,050 (71,212)5,257
152,522396,680
4,535,4091,786,685
20226306.16510
2.1841.708
Leap20216302.9524.138
1,7601.363
?2022
20226308.69111
1,1509,5407,50020216305.43520
148,090850750
20226302,8801.154
6,7601,90020216301.4311.126
3,5601,0801,600
20226305307,120
?2022
20205
?2022
2022630
71,36414,28257,082109,70051,35858,342565,936380,729185,207
40,90913,89627,013698,687254,109444,578
12,7504,2508,500
25,1735,74319,4307,4841,5365,948308,141308,141–1,840,1441,034,044806,100
20226301.0976,500BMS4,470BMS
?2022
3.8071.852
12.5
2022630
6.987
1,50020226301,280
2021620226302,520
2022630
20226303.081
?2022
427,5202022429
2022630
20226302021123145444307201222
20226
1002022630660660
?2022
2022630202112311.7234.831
20052022630202112315.1%
2.3%20226301.177
?2022
1994(PBOC)
2022630
20226302021123110.1%10.7%20226
2022630
?2022
2022630
2022630
20226308,600202112318,000
2022630662.22021630445.1
?2022
20226304.3202112317.2
2022630
132.120211231145.8
202263020211231
20226302021630
?2022
2022630XV
(a)XV78
(b)352(c)
(1)25,570,653
(2)
1.90%
10,000,000
(3)
0.74%
102,188
(4)
0.01%
7,727,927
(5)
0.57%
29,439,115
(6)
2.19%
510,941
(7)
0.04%
545,597
(8)
0.04%
1,584,167
(9)
0.12%
16,026,717
(10)
1.19%
172,372
(11)
0.01%
4,253,998
(12)
0.32%
1,127,542
(13)
0.08%
(14)
0.000004%
Margaret Han Dugan73,918
(15)
0.01%
Donald W. Glazer3,150,782
(16)
0.23%
Michael Goller413,335
(17)
0.03%
Anthony C. Hooper143,988
(18)
0.01%
Ranjeev Krishana413,335
(19)
0.03%
Thomas Malley1,326,083
(20)
0.10%
Alessandro Riva73,918
(21)
0.01%
Corazon (Corsee) D. Sanders104,117
(22)
0.008%
404,053
(23)
0.03%
?2022
(1) 20226301,344,123,362
(2) (1)1,627,205(2)23,499,740
(3)443,708
(3) Roth IRA PENSCO
(4) The John Oyler Legacy Trust
(5)
(6) Oyler Investment LLC
Oyler Investment LLC 99%
(7) The Oyler Family Legacy Trust
(8) 545,597(9)
(10) (1)5,693,991(2)10,219,971
(3)112,755(11)
(12) Wang Investment LLCWang Investment LLC99%(13)(14)
(15) (1)DuganDugan57,226
(2) Dugan16,692
?2022
(16) (1)Glazer2,746,729(2)GlazerGlazer379,561(3) Glazer24,492
(17) (1)Goller17,082(2)GollerGoller379,561
(3) Goller16,692
(18) (1)HooperHooper119,496
(2) Hooper24,492
(19) (1) Krishana17,082(2)KrishanaKrishana
379,561(3) Krishana16,692
(20) (1)Malley407,082(2)MalleyMalley902,309(3) Malley16,692
(21) (1)RivaRiva57,226
(2) Riva16,692
(22) (1) Sanders7,800(2)SandersSanders
79,625(3) Sanders16,692
(23) (1)7,800(2)379,561
(3)16,6922022630
(a)XV7
(b)352(c)
?2022
2022630
XV23
(1)
Amgen Inc.246,269,42618.32%Julian C. Baker
(2)
152,875,36311.37%Felix J. Baker
(2)
152,875,36311.37%Baker Bros. Advisors (GP) LLC
(2)
152,419,70311.34%Baker Bros. Advisors LP
(2)
152,419,70311.34%Baker Brothers Life Sciences Capital, L.P.
(2)
139,823,42310.40%HHLR Fund, L.P.
(3)
129,433,0599.63%HHLR Advisors, Ltd.
(3)
133,587,6559.94%The Capital Group Companies, Inc.
(4)
106,958,9257.96%
?2022
(1) 20226301,344,123,362
(2) Julian C. BakerFelix J. BakerBaker Bros. Advisors (GP) LLCBaker Bros. Advisors (GP) LLC
Baker Bros. Advisors LPBBABBA667, L.P.Baker Brothers Life Sciences, L.P.Baker Brothers Life Sciences Capital, L.P.Baker Brothers Life Sciences, L.P.
BBAMichael GollerRanjeev Krishana
BBABaker Brothers Life Sciences Capital, L.P.2021121520211215140,543,649Baker Brothers Life Sciences, L.P.Julian C. BakerFelix J. BakerBaker Bros. Advisors (GP) LLCBBA667, L.P.
11,152,058Baker Brothers Life Sciences, L.P.140,543,649723,996
BBABaker BrothersLife Sciences Capital, L.P.Baker Brothers Life Sciences, L.P.140,543,649723,996
BBAJulian C. BakerFelix J. Baker270,868FBB3 LLC151,004
(3) (i)133,587,655HHLR Fund, L.P. YHG Investment, L.P.(ii) 13,447,603HillhouseBGN Holdings LimitedHHLR Adrisors, Ltd.YHG Investment, L.P.HHLR Fund,L.P.Hillhouse Capital Management, Ltd.Hillhouse Fund II, L.P.Hillhouse Fund II, L.P.Hillhouse BGN Holdings LimitedHHLR Adrisors, Ltd.
HHLR Fund, L.P.YHG Investment, L.P. 133,587,655Hillhouse CapitalManagement, Ltd.Hillhouse BGN Holdings Limited13,447,603Hillhouse Fund II, L.P.Hillhouse BGN Holdings Limited13,447,603
(4) (i)13,112,463Capital International, Inc.(ii) 628,966Capital International Limited
(iii) 2,112,024Capital International Sarl(iv) 89,056,893Capital Research andManagement Company(v) 2,048,579Capital Group Private Client Services, Inc.Capital Group International, Inc.Capital Research and Management CompanyCapitalInternational, Inc.Capital International LimitedCapital International SarlCapital Group Private ClientServices, Inc.Capital Group International, Inc.Capital Bank and Trust CompanyThe CapitalGroup Companies, Inc.Capital Research and Management CompanyCapital Group International, Inc.Capital International, Inc.Capital International LimitedCapitalInternational SarlCapital Group Private Client Services, Inc.17,804,323Capital Research and Management CompanyThe Capital Group Companies Inc.The Capital Group Companies Inc.Capital Research and Management Company
106,958,925
2022630
XV23
?2022
1. 2011
201141520154172011201622201620112011
202263020112402011
201152020161312011
0.011.85
201120187302022112,908,297201120226302,702,945201120221120226302011
2022
2022
2011520
(1)
100.01–––––201343
(1)
100.01879,267–––879,2672015629
(1)
100.50500,000–––500,000Thomas Malley2016125
(2)
101.85552,752–––552,752
201276
(3)
100.0112–––12201343
(3)
100.0112–––122015629
(3)
100.511–––112011520 2016131
(3)
100.01
1.85
976,243–205,3484770,891
2,908,297–205,34842,702,945
?
2022
(1) 20%80%20%48(2)
(3) 20%/25%80%/75%20%/25%48/36
2. 2016
2018117201812720162016114201620226302016
74,437,2325.54%2022825201676,217,465
20228255.67%2016202041320206172016201657,200,0002016203020224172022622201620162016201666,300,000
2016
2016
?2022
20162022622
10%2016
30%
2016
1%
(i)
1/13(ii)
2016
201620162030413
?2022
2016202263020161,0662016201628202263020160.528.81
20161620221154,065,0732016202263063,489,6982016
(1)(2)
2022
2022
20161116
(3)
102.792.842,047,500–––2,047,500 2017927
(3)
106.737.70935,000–––935,0002018430
(3)
1013.3713.04996,810–––996,8102018626
(3)
1012.7012.341,310,088–––1,310,088201965(3)
109.259.232,193,282–––2,193,2822020617
(3)
1013.3313.421,821,976–––1,821,9762021616
(3)
1025.5426.53906,906–––906,9062022622
(3)
1011.7411.98–1,887,678––1,887,67820161116
(3)
102.792.841,613,430–––1,613,4302017927
(3)
106.737.70750,000–––750,0002018626
(3)
1012.7012.34655,044–––655,044201965(3)
109.259.23747,708–––747,7082020617
(3)
1013.3313.42560,599–––560,5992021616
(3)
1025.5426.53241,839–––241,8392022622
(3)
1011.7411.98–471,913––471,913Anthony C. Hooper202033
(5)
1012.6212.2221,970–––21,9702020617
(5)
1013.3313.4245,383–––45,3832021616
(5)
1025.5426.5317,498–––17,4982022622
(5)
1011.7411.98–34,645––34,645
?2022
(1)(2)
2022
2022
201628(4)
102.612.42188,926–––188,926201762
(5)
102.943.1565,988–––65,988201866
(5)
1015.7316.1517,442–––17,442201965
(5)
109.259.2364,610–––64,6102020617
(5)
1013.3313.4245,383–––45,3832021616
(5)
1025.5425.6317,498–––17,498Margaret Han Dugan2022228
(5)
1016.4716.22–22,581––22,5812022622
(5)
1011.7411.98–34,645––34,645Donald W. Glazer2017419
(4)
102.842.83199,992–––199,992201866
(5)
1015.7316.1517,442–––17,442201965
(5)
109.259.2364,610–––64,6102020617
(5)
1013.3313.4245,383–––45,3832021616
(5)
1025.5425.6317,498–––17,4982022622
(5)
1011.7411.98–34,645––34,645Michael Goller2017419
(4)
102.842.83199,992–––199,992201866
(5)
1015.7316.1517,442–––17,442201965(5)
109.259.2364,610–––64,6102020617
(5)
1013.3313.4245,383–––45,3832021616
(5)
1025.5425.6317,498–––17,4982022622
(5)
1011.7411.98–34,645––34,645Ranjeev Krishana2017419
(4)
102.842.83199,992–––199,992201866
(5)
1015.7316.1517,442–––17,442201965(5)
109.259.2364,610–––64,6102020617
(5)
1013.3313.4245,383–––45,3832021616
(5)
1025.5425.6317,498–––17,4982022622
(5)
1011.7411.98–34,645––34,645Thomas Malley201762
(5)
102.943.15169,988–––169,988201866
(5)
1015.7316.1517,442–––17,442201965(5)
109.259.2364,610–––64,6102020617
(5)
1013.3313.4245,383–––45,3832021616
(5)
1025.5425.6317,498–––17,4982022622
(5)
1011.7411.98–34,645––34,645Corazon D. Sanders2020824
(5)
1018.5018.2627,482–––27,4822021616
(5)
1025.5425.6317,498–––17,4982022622
(5)
1011.7411.98–34,645––34,645
?2022
(1)(2)
2022
2022
Alessandro Riva2022228
(5)
1016.4716.22–22,581––22,5812022622
(5)
1011.7411.98–34,645––34,645201841
(4)
1012.9212.7263,290–––63,290201965
(5)
109.259.2364,610–––64,6102020617
(5)
1013.3313.4245,383–––45,3832021616
(5)
1025.5425.6317,498––17,498–2017419
(4)
102.842.83199,992–––199,992201866
(5)
1015.7316.1517,442–––17,442201965
(5)
109.259.2364,610–––64,6102020617
(5)
1013.3313.4245,383–––45,3832021616
(5)
1025.5425.6317,498–––17,4982022622
(5)
1011.7411.98–34,645––34,6452018430
(6)
1013.3713.04766,599–––766,599 201965
(3)
109.259.23797,550–––797,5502020617
(3)
1013.4213.33756,821–––756,8212021616
(3)
1025.5425.63483,678–––483,6782022622
(3)
1011.7411.98–1,061,814––1,061,8142020630
(3)
1014.5514.66104,754–––104,7542021616
(3)
1025.5426.53177,853–––177,8532022622
(3)
1011.7411.98–589,888––589,8882016713
(3)
102.2723.632.29233,948–233,948––2017627
(3)
103.503.49999,999–999,999––2018626
(3)
1012.7012.34364,208–––364,208201965(3)
109.259.23558,285–––558,2852020617
(3)
1013.3313.42525,564–––525,5642021616
(3)
1025.5426.53332,527–––332,5272022622
(3)
1011.7411.98–707,876––707,876201692(3)
102.2626.042.27207,575–––207,575 2017627
(3)
103.503.49850,465–––850,4652018626
(3)
1012.7025.5712.34122,798–––122,798201965
(3)
109.2527.349.23211,276–––211,2762020617
(3)
1013.3325.5713.42204,971–––204,9712021616
(3)
1025.5426.53157,196–––157,196
?2022
(1)(2)
2022
2022
2016713
(3)
102.272.293,262,835–––3,262,8352016722
(3)
102.1312.472.10105,487–6,500–98,9872016722
(6)
102.1313.992.10981,325–84,48711896,8272016729
(3)
102.112.0226–––26201689
(3)
102.042.10–––––2016822
(3)
102.282.24–––––2016912
(3)
102.332.42–––––2016919
(3)
102.512.38–––––2016926
(3)
102.352.27–––––20161012
(3)
102.482.42134,498–––134,49820161012
(6)
102.482.421,020–––1,02020161017
(3)
102.422.5561,399–––61,3992016111
(3)
102.562.57–––––2016117
(3)
102.432.46–––––2016118
(3)
102.462.51–––––20161116
(3)
102.792.84–––––20161121
(3)
102.462.42–––––20161128
(3)
102.4917.482.3839,000–39,000––20161130
(3)
102.432.441,274–––1,2742016121
(3)
102.442.37–––––2016129
(3)
102.072.0934,099–––34,099201713
(3)
102.3412.632.3916,965–9,165–7,800201715
(3)
102.442.3963,661–––63,661201719(3)
102.3717.942.43158,496–6,500–151,9962017117
(3)
102.512.53–––––2017117
(6)
102.5113.762.5388,556–6,591–81,9652017123
(3)
102.4613.532.49108,875–57,330–51,5452017130
(3)
102.802.62–––––201721
(3)
102.682.77144,989–––144,989201726(3)
102.762.7632,201–––32,201201728(3)
102.672.78–––––2017213
(3)
102.7713.802.7771,643–15,600–56,0432017227
(3)
102.972.93–––––201736
(3)
103.143.06–––––2017313
(3)
103.083.02142,701–––142,7012017320
(3)
103.043.0484,968–––84,9682017327
(3)
102.792.79–––––2017331
(6)
102.8114.932.8285,683–24,999–60,684201743(3)
102.822.825,928–––5,9282017410
(3)
102.862.91–––––2017411
(3)
102.912.95–––––2017417
(3)
102.9214.402.95109,590–17,368–92,2222017424
(3)
102.822.89–––––2017426
(3)
103.013.09–––––201751
(3)
103.143.13531,245–––531,245
?2022
(1)(2)
2022
2022
201752
(6)
103.1311.923.12115,349–2,418416112,515201753
(3)
103.123.1211,999–––11,999201758
(3)
103.022.98–––––2017510
(3)
102.882.92–––––2017515
(3)
102.812.909,100–––9,1002017530
(3)
102.882.8821,060–––21,060201761
(6)
102.8314.672.941,150,045–32,8125071,116,7262017612
(3)
102.9910.693.0012,844–117–12,7272017614
(3)
103.0414.593.05776,581–44,239–732,3422017615
(6)
103.0513.773.044,029,896–339,23510,0883,680,5732017621
(3)
103.313.4517,784–––17,7842017623
(3)
103.413.45–––––2017627
(3)
103.503.492,233,309–––2,233,3092017629
(3)
103.503.4543,654–––43,6542017710
(3)
105.4012.815.45156,624–32,500–124,1242017717
(3)
105.6713.244.1941,106–29,120–11,9862017717
(6)
105.6712.194.19366,366–38,064–328,3022017724
(3)
105.955.65–––––2017731
(3)
105.5815.505.42119,574–14,9114,66799,9962017731
(6)
105.5813.675.42371,072–5,005–366,067201781
(3)
105.4212.505.58473,200–83,200–390,000201782
(6)
105.585.45–––––201783
(3)
105.455.5119,994–––19,994201787(3)
105.565.95114,309–––114,309201788
(3)
105.956.0312,649–––12,6492017810
(3)
105.955.59–––––2017811
(3)
105.595.46–––––2017817
(3)
105.395.3218,317–––18,3172017825
(3)
105.385.29–––––2017828
(3)
105.295.2824,167–––24,1672017831
(3)
105.305.30–––––2017831
(6)
105.3011.145.30281,242–50,5183,471227,253201795
(3)
105.785.68269,997–––269,9972017912
(3)
105.395.43–––––2017913
(3)
105.435.82–––––2017918
(3)
106.226.3722,269–––22,2692017922
(3)
106.5316.626.5590,155–21,567–68,5882017925
(3)
106.5511.726.56153,569–31,577–121,9922017926
(3)
106.568.71–––––2017929
(3)
107.497.9637,492–––37,4922017111
(3)
107.106.84226,356–––226,35620171130
(3)
106.386.1510,764–––10,764201815(3)
107.727.5819,071–––19,0712018131
(3)
109.5212.7910.4484,385–3,393–80,9922018228
(3)
1011.6111.047,904–––7,904
?2022
(1)(2)
2022
2022
2018430
(3)
1013.3713.0417,407––11,2586,1492018626
(3)
1012.7014.8612.34935,961–18,2523,042914,6672018629
(3)
1011.9011.8312,103–––12,1032018831
(3)
1013.6713.6613,741–––13,7412018831
(7)
1013.6713.66108,537–––108,5372018928
(3)
1013.2813.2565,433–––65,4332018928
(8)
1013.2813.2539,260–––39,26020181130
(3)
1011.0711.7911,028–––11,02820181231
(3)
1010.5319.7310.79144,053–1,989–142,06420181231
(8)
1010.5310.7912,727–––12,7272019125
(3)
109.6210.4438,649–––38,6492019228
(3)
1010.7710.54130,754–––130,754201935
(3)
1011.6811.5178,494–––78,4942019510
(3)
109.3310.3244,213–––44,213201965
(3)
109.2515.209.233,074,162–91,87185,6442,896,6472019628
(3)
109.679.5338,714––24,60914,1052019830
(3)
1011.1411.0697,201–––97,20120191129
(3)
1015.7115.8339,221–––39,22120191231
(3)
1012.8012.9229,523–––29,523202033
(3)
1012.6212.1920,657–––20,6572020331
(3)
109.659.67294,775–––294,7752020512
(3)
1012.5612.1838,597–––38,5972020529
(3)
1012.4912.7321,281–––21,2812020617
(3)
1013.3316.5413.422,220,140–14396,1482,123,8492020630
(3)
1014.5514.66212,771–––212,771202087
(3)
1017.2416.9940,248–––40,2482020831
(3)
1018.6918.8514,040––8,5285,5122020930
(3)
1021.6522.038,021–––8,0212020116
(3)
1023.0823.07175,708–––175,70820201130
(3)
1021.9920.9926,962––8,03418,9282021122
(3)
1027.4628.8164,441––9,17855,2632021226
(3)
1025.3625.816,331–––6,3312021331
(3)
1025.6126.78158,834––10,010148,824202157
(3)
1024.1524.7884,240–––84,2402021528
(3)
1027.0027.58121,485–––121,4852021616
(3)
1025.5426.532,333,955––70,1612,263,7942021630
(3)
1027.4827.2888,829––29,43259,397202186
(3)
1025.8425.61158,262–––158,2622021
(3)
1023.2223.72153,322–––153,3222021930
(3)
1027.8128.7361,230–––61,2302021115
(3)
1028.3828.0845,786–––45,78620211130
(3)
1026.4026.8564,649–––64,64920211231
(3)
1021.0320.8459,332–––59,3322022127
(3)
1017.2718.61–371,059––371,0592022228
(3)
1016.4716.22–171,626––171,626
?
2022
(1)(2)
2022
2022
2022331
(3)
1015.8515.46–135,694––135,694202256
(3)
1012.2712.50–80,821––80,8212022531
(3)
1010.3010.56–123,604––123,6042022622
(3)
1011.7411.98–6,122,831––6,122,8312022630
(3)
1012.4812.81–77,974––77,974
54,065,07312,159,7452,342,418392,70263,489,698
(1) 13
(2) 13
(3) 25%
75%25%36(4)(5)
(6) 20%80%20%48
(7) 48(8)
?2022
201620226222022419
2022622202225,6936,423AnthonyC.HooperMargaret Han DuganDonald W. GlazerMichael GollerRanjeevKrishanaThomas MalleyAlessandro RivaCorazon (Corsee) D. Sanders
1,284567,736
3. 2018
20181172018127201820186620182019652018
202162018
202191201820226302,827,9292018
201815%20182018
201820185%
?2022
2018
1%10%25,000
319185%
2018
4. 2018
201866201812,000,0002018
2018872018202263020182018
2018831201813.662021123120189,334,659
0.7%
20226302018202262220189,372,8952022630
0.7%
?2022
20226222016201820181620221130,90120182022630
30,9012018
(1)(2)
2022
2022
2018831
(3)
1013.6725.4913.6630,901–––30,901
30,901–––30,901
(1) 13
(2) 13
(3) 25%
75%25%36
2018
5635(c)(4)2018
?2022
201812,000,00020182018202262220162018
2018
1%
(i)
1/13(ii)
2018
?2022
C.2.1
Ranjeev Krishana
?
2022
3.21D.3.3D.3.7
Thomas MalleyCorazon(Corsee) D. SandersAnthony C. HooperThomas Malley
3.10(2)3.21
3.25E.1.2
Margaret Han DuganRanjeev KrishanaMargaretHan Dugan2022622Margaret Han Dugan2022913
B.3.1
Donald W. GlazerMichael GollerAlessandro RivaAnthony C. HooperDonald W. Glazer
?2022
B.8
202211
?2022
13.51(B)(1)
13.51(B)(1)
2022131
Margaret Han Dugan202221
2022225Alessandro Riva202221
2022622
Margaret Han Dugan2022913
202012
174.8515,895,001206,635,013
20.5%2,779,241,000(a)201910303036%(b)
1.007.842019103126%(c)2019103126%
?2022
201911292022630
(%)
20211231
2022
2022
(a)
2,779,241100%1,869,6431,984,939794,302
(a) 12.5
20191129
2025201911120191292020132020924
20.6%
20.4%
75,000,000
2020121(a)20%(b)60(c)
?2022
20203182020925202010
20219165,5292,151,87750,000,000202263050,000,0002020720207152020
202,995,3382020712
14.2308185145,838,979
20.8
(a)
(b)(c)
(d)
20207132020716202263019.21.5
?2022
20211215)20216162021
192.60234.89391.68115,055,2603,392,616,000()(i)(ii)(iii)(iv)(v)
20201116202112920214202021514202161202162120216282021630202179202172820211015202111162021112320211124202111292021113020211222021126202112720211213202112212021122820224292021430
?2022
202263047169
2022630
20211231
2022
2022
13,245,940–3,309,5499,936,391467,700–348,120119,580150,000–91,09258,908136,360–62,20774,1536,000,000–913,7985,086,2021,630,155––1,630,15521,630,155–4,724,76616,905,389
2022630
?2022
2022202163020222021630
30003000(i) 2323
20222021630202263020211231(ii) 23(iii) 23
?2022
3000
(i) 23(ii) 23(iii) 23
Thomas MalleyAnthony C. HooperCorazon (Corsee) D.SandersThomas MalleyCorazon (Corsee) D. SandersAnthony C.HooperThomas Malley
2022630
?2022
2022630
13.2013.2113.22
2022826
?2022
20222021
13566,084244,741 382,114511,123 648,198755,864 136,41068,948 768,122676,817 625,976414,395 376375 1,530,8841,160,535
(882,686)(404,671) 21,502(9,045) (117,650)(4,990)
(978,834)(418,706)926,889(4,860)
(1,005,723)(413,846)
(0.75)(0.35)151,334,252,6481,191,521,766 (9.80)(4.52)
102,634,81991,655,520
?2022
20222021(1,005,723)(413,846) (88,085)5,864 –361 (12,315)(1,072)
(1,106,123)(408,693)
?2022
202220216301231
4,531,1374,375,678 4333328 41,172,5542,241,962 5172,259483,113 6262,210242,626 10207,383270,173
6,345,8767,613,880 43,9396,881 7633,100587,605 117,583117,431 843,32546,679 9103,429110,424 10130,955163,049
1,032,3311,032,069
7,378,2078,645,949
11234,355262,400 10454,183558,055 3163,396187,414 915,56421,395 24,78821,925 3125,394120,801 12380,729427,565
1,398,4091,599,555
?2022
202220216301231
12185,207202,113 3167,570220,289 41,92143,041 914,73914,169 3219,385269,561 1048,43254,234
677,254803,4072,075,6632,402,962
0.0001 9,500,000,000 202263020211231 1,349,639,439 1,334,804,281134133 11,356,68611,191,007 17(82,450)17,950 (5,971,826)(4,966,103)
5,302,5446,242,9877,378,2078,645,949
?2022
202112311,334,804,28113311,191,00717,950(4,966,103)6,242,987 ––(152)––(152) 2,165,904–––––
12,669,254118,971––18,972 ––146,860––146,860 –––(100,400)–(100,400) ––––(1,005,723)(1,005,723)20226301,349,639,43913411,356,686(82,450)(5,971,826)5,302,544202012311,190,821,9411187,414,9326,942(3,552,749)3,869,243 (1,722,773)–––––
15,467,855235,599––35,601 ––110,624––110,624 –––5,153–5,153 ––––(413,846)(413,846)20216301,204,567,0231207,561,15512,095(3,966,595)3,606,775
?2022
20222021
(1,005,723)(413,846) 32,06121,159 16146,860110,624 423,5296,033 –53,500 3(45,583)(53,902) 7,550(12,311) 6,36011,212 307,430(13,338) (31,633)(28,294) 32,315(77,204) (30,362)(42,558) 19,5251,688 (76,737)138,877 (2,114)3,189
(616,522)(295,171) (95,421)(80,920) (11,504)(1,357,051) 1,051,0281,997,515 (75,000)(8,500) –(7,500)
869,103543,544
?2022
20222021
12–10,819 1267,586112,589 12(115,405)(15,959) 18,97235,601
(28,847)143,050(71,212)5,257152,522396,6804,382,8871,390,0054,535,4091,786,685 4,531,1371,776,448 333310 3,9399,927 24,43614,527 12,89914,267 58,67628,885 –45,000
?2022
1.
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316,000
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?2022
1.
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BeiGene 101–100%BeiGene AUS Pty Ltd BeiGene Australia
56,947,230100%
*
902,345,067
100%
*
10,450,000,000
100%BeiGene (Canada) ULC100100%BeiGene ESP, S.L.3,000100%BeiGene France Sarl7,500100%
*
8,870,000,000
100%
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BeiGene Germany GmbH25,000100%BeiGene (Hong Kong) Co., Limited
7,700,000,000
100%
*4,000,000100%
?2022
BeiGene International GmbH20,000100%BeiGene (Italy) S.R.L10,000100%BeiGene Brazil Ltda.2,450,190100%BeiGene Poland sp. z o.o.5,000100%BeiGene Sweden AB25,000100%BeiGene Turkey Medical Products Trade Limited Company
10,000100%BeiGene Ireland Limited BeiGene Ireland
–100%BeiGene Japan, Ltd.1,781,660100%BeiGene Korea Y.H.100,000,000100%BeiGene Netherlands B.V–100%BeiGene NZ Unlimited BeiGene NZ, Limited
100,000100%BeiGene Pharmaceuticals GmbH20,000100%
1.
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*
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*
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*
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270,000,000
100%BeiGene Singapore Pte. Ltd.1100%
*
2,673,218,389
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20,000100%
1.
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1.
202263020222021630202220216302022
2021630
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2022630
?2022
2.
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?2022
2.
20211231123
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202263020211231
?2022
3.
2022202163020222021630
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5,377–82,114511,123
20211
?2022
3.
650,000,0001,300,000,000250,000,000
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?2022
3.
650,000,000
1,231,000,000420,000,000484,646,000
165,354,00020216302021630
202263020,656,000202163026,477,00020226305,377,000
?2022
3.
202112
TIGIT
?????2022
20221300,000,000202320232023600,000,000700,000,000
745,000,0001,150,000,000
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(1)
(2)(3)
(4)
?2022
3.
300,000,000
71,980,000213,450,00014,570,000
?2022
3.
202263052,497,00020226303,584,000
201910
???
202012????XGEVA
?201920201120207
?202012
?B20217
?
20224
?
CD19B
?2022
3.
1,250,000,000KRAS G12CLUMAKRAS?(sotorasib)LUMAKRAS?
808100%
2022420
?2022
3.
201910202012174.8515,895,001
20.5%
Anthony Hooper20201
132.74
2,109,902,000601,857,0002,779,241,0002,162,407,000616,834,00020222021630
2022202146,78955,33045,58353,90392,372109,233
2022
698,687
?
2022
3.
202263020211231
202220216301231125,394120,801219,385269,561344,779390,36220222021630
20222021
3,47867889863
(26,642)(15,917)
(22,266)(15,176)202263030,061,000202163018,854,00020226
3020211231101,580,000106,790,000
?2022
4.
2022630202112314,272,0007,209,000
2022630
1,184,869–12,3151,172,5541,184,869–12,3151,172,55420211231
2,245,662–3,7002,241,9622,245,662–3,7002,241,96220226302022630
?2022
4.
Leap Therapeutics, Inc. (Leap)20201Leap5,000,000Leap BB20203LeapLeap20219Leap7,250,000
Leap2022630Leap
8.3%Leap
13.1%
202263022,661,00020216305,376,000202263020211231
202220216301231Leap8,45123,809Leap3,00310,306
20226302021123144,033,000
43,722,0002022630
366,000
?2022
4.
20226302021123127,100,00022,955,00020226301,234,0002021630657,0005.
202220216301231172,467483,528
(208)(415)
172,259483,1134590
20222021
63012313171,294483,0583696555
172,259483,113
?2022
5.
20222021630
20222021415112
(210)(46)
––
20867
6.
20222021630123182,84878,14037,9929,397141,370155,089262,210242,626
?2022
7.
20222021630123165,48565,485131,885118,203
50,87850,288179,495144,083138,478119,585
36,47327,404602,694525,048(142,561)(124,286)172,967186,843633,100587,60520211175,197,00042
202263030,041,000202163020,667,000
?2022
8.
202263020211231
202263020211231
7,500(3,625)3,8757,500(3,250)4,250 42,016(2,566)39,45043,394(965)42,429 816(816)–816(816)–
50,332(7,007)43,32551,710(5,031)46,679BMS
2018920202
20242
?2022
8.
20222021
1,644117
3763752,0204922022630123120221,6143751,98920233,2227503,97220243,2227503,97220253,2227503,97220263,2227503,972202724,94850025,448
39,4503,87543,325
?2022
9.
202263026,889,0002021630
4,860,0002022630
2021630
2022
202263011,765,00012
20226301,840,000
2022630202112
20226302013202220122022
2018202220152022
20112022
?2022
10.
20222021630123172,47487,23959,29178,53818,62758,57917,40912,0102,6115,0528,4621,69528,50927,060207,383270,173
202220216301231109109
14,41214,140
(1)
21,47324,2372917,1627,3456,609487,587100,792
130,955163,049(1)
?2022
10.
202220216301231124,565139,966151,321213,92255,36671,56023,52545,66171,51259,63927,89427,307454,183558,055
202220216301231
40,83546,352
7,4847,81411368
48,43254,234
?2022
11.
2022202163012313229,217257,977361,7253,210613,1371,1101276103
234,355262,400
12.
202263020211231
202263020211231
201844580,0009202744(1)4,33029,0001,2558,0002020122(2)92029120(2)1,49310,0001,56910,0002020119378,00092029118(3)2,61317,500––2020924200,000(4)4.5%200,0001,339,585200,0001,274,5352020924500,000(5)4.5%14,930100,00015,693100,000202222550,000120232252.2%50,000334,896––
(6)107,363719,115209,0481,332,197
380,7292,550,096427,5652,724,732201844580,0009202744(1)81,368545,00089,444570,0002020122(2)92029120(2)50,016335,00053,353340,0002020119378,00092029118(3)53,823360,50059,316378,000
185,2071,240,500202,1131,288,000
?2022
12.
1. 2022630
4.9%
2022630598,0004,000,000
2. 2020122
1,100,000,000
202012311,100,000,000350,000,0002022630
4.4%2022630771,0005,000,000201733
3. 2022630
4.3%
4. 20209200,000,000
120,000,00080,000,000
202110820211082022108
2017125
5. 20209
73,640,000500,000,00014,728,000100,000,00058,912,000400,000,000(i)2021119
(ii)2021108(i)2022119(ii)Hillhouse CapitalHillhouse CapitalHillhouse Capital
6. 2021123120201231
1,760,000,00020214192023524202263017,586,000117,000,000
114,036,000730,082,0002022630
4.1%
?2022
12.
202263010,984,0001,935,000202163014,577,000251,000
13.
?????????
20222021630
20222021638,273291,794(72,189)(47,053)566,084244,74120222021630
20222021?
233,07264,513?
192,522123,758?
41,57626,775?
29,00817,792?
19,798–?
21,396–
?
8,405–
?
8,9466,961
?
4,5772,2216,7842,721566,084244,741
?2022
13.
20222021630
2022202159,63911,87472,18947,053(60,316)(33,355)71,51225,57214.
20222021136,41068,94830,04120,784768,122676,81713,36610,1412,020375489,416316,935146,860110,632
25,96617,523662,242445,090118,3552,460
(32,520)(5,534)73–
20222021630293,291,000220,110,000
?2022
15.
20222021
(1,005,723)(413,846) 1,334,252,6481,191,521,766
20222021630
16.2016
20161NASDAQ(IPO)201620162016265,029,595
201620112011
20162011
2022630201120165,166,510201812201638,553,15920206
201657,200,000203041320162022630201612,159,74533,193,771
2022630201663,489,64957,144,9062022630201674,479,333
?2022
16.2016
20162016
201666,300,00020223315%20226222018201862018201812,000,000
5635(c)(4)5635(c)(4)20182018
201620188
2018202263020182022630201830,901408,408
201620182022622
?2022
16.
20182018620183,500,000201812
3,855,3157,355,3152019620216
202191
15%
10%20226304,527,386
2022228667,160210.5216.19178.9413.769,1832021831425,386308.3023.72262.0620.168,5752021226436,124236.3018.18200.8615.456,738
1.
2.
?2022
16.
20222021630
2022202167,96552,08278,89558,542146,860110,62417.
2021123127,898(3,700)(6,248)17,950
(88,085)(12,315)–(100,400) ––––
(88,085)(12,315)–(100,400)2022630(60,187)(16,015)(6,248)(82,450)
?2022
18.
201910312019126202092420219165,5292,151,87750,000,000
202112
192.60
391.68115,055,260
3,392,616,00019.
10%50%
?2022
19.
10%
2022630202112312,448,530,000799,574,000
20.
2022630109,700,00065,020,000
44,680,000
2022630308,141,000
1,250,000,0002022630
698,687,000
?2022
20.
20216202263025,173,000
15,000,000202263012,750,000
20226301,536,000
CRO
?2022
21.(a) 20222021630 20222021
630(i)50,000202150,000(ii)75,000202175,000(iii)
2,141,00020212,271,000(b)
20222021
3,4232,945376519,62617,63523,08620,645
?2022
22.
20222021403,164218,617213,749383,80931,285153,438648,198755,864202220216302022630
57,480,000
?
156,269,0002021630357,786,000
?
26,023,000202263024,634,000
?
6,651,0002021630
?2022
23.
2022630
(i)(iii)(768,122)(5,520)–(773,642)(625,976)(4,044)–(630,020)(978,834)(9,564)–(988,398)
(26,889)1,082(11,385)(37,192)(1,005,723)(8,482)(11,385)(1,025,590)(1,005,723)(8,482)(11,385)(1,025,590)
?2022
23.
2021630
(i)(iii)(676,817)34,210–(642,607)(414,395)18,197–(396,198)(418,706)52,407–(366,299)
4,860(4,125)(21,801)(21,066)(413,846)48,282(21,801)(387,365)(413,846)48,282(21,801)(387,365)
?2022
23.
2022630
(i)(ii)(iii)103,4291,082–(9,662)110,169
15,320
*
––7,378,20716,402–(9,662)7,384,94711,356,6869,564307,894
*
1,72311,985,971174,049*
–136,055
*(5,971,826)(9,564)(307,894)
*
(11,385)(6,594,371)1,082––(158,729)*
–(136,055)
*5,302,54416,402–(9,662)5,309,284
?2022
23.
20211231
(i)(ii)(iii)110,4245,253––125,744
10,067*––8,645,94915,320––8,661,26911,191,00748,730–56,23711,809,005
125,319*307,894*79,818*(4,966,103)(48,730)–(56,237)(5,568,781)
5,253––
(115,252)*(307,894)*(79,818)*6,242,98715,320––6,258,307*
(i)
20226309,564,000202163052,407,00020226301,082,00020216304,125,000
?2022
23.
(i)
20211231
174,049,00015,320,000158,729,00020211231202211(ii)
20162307,894,000
307,894,000
?2022
23.
(iii)
2016-
20226309,662,0002021630
20226301,723,000202163021,801,000
20211231136,055,000136,055,000
202211(iv)
20226302022630
?2022
23.
(v)
20226302022630
24.
20226302021630
?2022
2011201141520154172011201620161142016
2022429201820181172018127
2018201866
201820216162021912018 2018
2018662018872018ADS13
198747
20191031202012
201910312018127
?2022
20101028
2017125201733BeiGene Switzerland GmbH201791
?2022
FDA(U.S. Food and Drug Administration)
19981127
?2022
NMPA(National Medical Products Administration)
Novartis Pharm AG
20187302022630
?2022
?2022
BLABRAFB-rafBTKBCLLESCC
MCL
PARPADP
DNADNAPD-11Tpro-B
PD-L1PD-L2PD-1T
?2022
RAFRAFBRAF-BRAF
BRAF-CRAFCRAF-CRAFsBLASLL
TTT
BTIM-3T3Th1
WM