2021年度報告
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Anthony C. Hooper
Margaret Han Dugan
Donald W. GlazerMichael GollerRanjeev KrishanaThomas MalleyAlessandro Riva
Corazon (Corsee) D. Sanders
Thomas MalleyAnthony C. HooperCorazon (Corsee) D. Sanders
Ranjeev Krishana
Donald W. GlazerMichael GollerAnthony C. Hooper
Alessandro Riva
Corazon (Corsee) D. Sanders
Margaret Han Dugan
Michael GollerThomas MalleyAlessandro Riva
Anthony C. HooperMargaret Han Dugan
Ranjeev KrishanaCorazon (Corsee) D. Sanders
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Anthony C. Hooper67
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(McKinsey & Company)1990619961
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Corazon (Corsee) D. Sanders6520208Sanders(Bristol Myers Squibb Corporation)201911
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Anthony C. Hooper
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20211231
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152,875,36311.48%Baker Bros. Advisors (GP) LLC
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152,419,70311.45%Baker Bros. Advisors LP
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129,433,0599.72%Hillhouse Capital Advisors, Ltd.
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133,587,65510.03%The Capital Group Companies, Inc.
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103,974,3937.81%JPMorgan Chase & Co.
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11,433,3470.86%
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20211231
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2011415201541720112016222016201120112021123120112402011
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2021
20211231Anthony C. Hooper
202033
(5)
1012.6212.2221,970–––21,9702020617
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2017419
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20211231Michael Goller
2017419
(4)
102.842.83199,992–––199,992201866
(5)
1015.7316.1517,442–––17,442201965
(5)
109.259.2364,610–––64,6102020617
(5)
1013.3313.4245,383–––45,3832021616
(5)
1025.5425.63–17,498––17,498Ranjeev Krishana
2017419
(4)
102.842.83199,992–––199,992201866
(5)
1015.7316.1517,442–––17,442201965
(5)
109.259.2364,610–––64,6102020617
(5)
1013.3313.4245,383–––45,3832021616
(5)
1025.5425.63–17,498––17,498Thomas Malley
201762
(5)
102.943.15169,988–––169,988201866
(5)
1015.7316.1517,442–––17,442201965
(5)
109.259.2364,610–––64,6102020617
(5)
1013.3313.4245,383–––45,3832021616
(5)
1025.5425.63–17,498––17,498
?2021
(1)(2)
2021
20211231Corazon D. Sanders
2020824
(5)
1018.5018.2627,482–––27,4822021616
(5)
1025.5425.63–17,498––17,498201841
(4)
1012.9212.7263,290–––63,290201965
(5)
109.259.2364,610–––64,6102020617
(5)
1013.3313.4245,383–––45,3832021616
(5)
1025.5425.63–17,498––17,4982017419
(4)
102.842.83199,992–––199,992201866
(5)
1015.7316.1517,442–––17,442201965
(5)
109.259.2364,610–––64,6102020617
(5)
1013.3313.4245,383–––45,3832021616
(5)
1025.5425.63–17,498––17,498
2018430
(6)
1013.3713.04766,599–––766,599201965
(3)
109.259.23797,550–––797,5502020617
(3)
1013.4213.33756,821–––756,8212021616
(3)
1025.5425.63–483,678––483,678
?2021
(1)(2)
2021
2021123120206301014.5514.66104,754–––104,75420216161025.5426.53–177,853––177,853
20161116
(3)
102.7924.662.841,752,500–1,752,500––2017629
(3)
103.5023.983.451,250,000–1,250,000––2018626
(3)
1012.7025.1112.34364,208–303,26460,944–201965
(3)
109.2526.769.23558,285–325,520232,765–2020617
(3)
1013.3321.3613.42315,341–105,092210,249–2016713
(3)
102.2723.632.29824,993–591,045–233,9482017627
(3)
103.503.49999,999–––999,9992018626
(3)
1012.7012.34364,208–––364,208201965
(3)
109.259.23558,285–––558,2852020617
(3)
1013.3313.42525,564–––525,5642021616
(3)
1025.5426.53–332,527––332,527
?2021
(1)(2)
2021
20211231
201692
(3)
102.2626.042.27324,575–117,000–207,5752017627
(3)
103.503.49850,465–––850,4652018626
(3)
1012.7025.5712.34212,680–89,882–122,798201965
(3)
109.2527.349.23462,579–251,303–211,2762020617
(3)
1013.3325.5713.42273,286–68,315–204,9712021616
(3)
1025.5426.53–157,196––157,196
2016713
(3)
102.2724.432.293,705,717–442,858243,262,8352016722
(3)
102.1324.032.10285,394–179,907–105,4872016722
(6)
102.1324.812.101,538,927–547,7039,899981,3252016729
(3)
102.1121.252.0278–52–26201689
(3)
102.0425.942.1055,552–55,5493–2016822
(3)
102.282.24–––––2016912
(3)
102.3326.922.423,468–3,45810–
?2021
(1)(2)
2021
20211231
2016919
(3)
102.5122.442.3841,331–41,3274–2016926
(3)
102.3522.342.272,097–2,0934–20161012
(3)
102.4825.552.42199,498–65,000–134,49820161012
(6)
102.482.421,020–––1,02020161017
(3)
102.4227.752.5589,999–28,600–61,3992016111
(3)
102.562.57–––––2016117
(3)
102.432.46–––––2016118
(3)
102.462.51–––––20161116
(3)
102.7925.852.8418,434–18,434––20161121
(3)
102.4623.552.4232,890–32,890––20161128
(3)
102.4928.382.3868,471–29,471–39,00020161130
(3)
102.432.441,274–––1,2742016121
(3)
102.4424.632.3743,771–43,771––2016129
(3)
102.072.0934,099–––34,099201713
(3)
102.3426.922.3939,039–22,074–16,965
?2021
(1)(2)
2021
20211231
201715
(3)
102.4428.322.39244,998–181,337–63,661201719
(3)
102.3726.752.43184,496–26,000–158,4962017117
(3)
102.5126.232.537,644–7,644––2017117
(6)
102.5125.142.53119,782–31,226–88,5562017123
(3)
102.4624.592.49157,040–48,165–108,8752017130
(3)
102.8025.812.626,201–6,201––201721
(3)
102.6827.142.77296,998–144,3007,709144,989201726
(3)
102.7627.022.7653,001–20,800–32,201201728
(3)
102.6723.712.781,924–1,924––2017213
(3)
102.7725.782.77191,269–119,626–71,6432017227
(3)
102.9726.372.9367,418–67,418––201736
(3)
103.1424.913.0628,613–28,613––2017313
(3)
103.083.02142,701–––142,7012017320
(3)
103.0428.903.04205,517–120,549–84,9682017327
(3)
102.7923.302.7982,498–82,498––
?2021
(1)(2)
2021
20211231
2017331
(6)
102.8124.552.82197,366–88,06223,62185,683201743
(3)
102.8226.512.829,581–3,653–5,9282017410
(3)
102.8624.902.9139,962–39,962––2017411
(3)
102.9128.432.9522,022–12,4809,542–2017417
(3)
102.9226.142.95258,154–138,6979,867109,5902017424
(3)
102.8224.072.8988,257–88,257––2017426
(3)
103.0126.253.0973,177–73,177––201751
(3)
103.1427.073.13731,380–197,7822,353531,245201752
(6)
103.1325.313.12271,063–154,856858115,349201753
(3)
103.1225.593.1231,239–19,240–11,999201758
(3)
103.0225.182.9873,320–73,320––2017510
(3)
102.8826.012.9221,281–21,281––2017515
(3)
102.8127.902.90153,491–144,391–9,1002017530
(3)
102.8827.552.8860,060–39,000–21,060201761
(6)
102.8327.162.941,230,593–72,7487,8001,150,045
?2021
(1)(2)
2021
20211231
2017612
(3)
102.9927.833.0044,070–31,226–12,8442017614
(3)
103.0425.703.051,138,475–349,11512,779776,5812017615
(6)
103.0526.013.045,014,906–851,617133,3934,029,8962017621
(3)
103.3126.083.4539,234–21,450–17,7842017623
(3)
103.413.45–––––2017627
(3)
103.5027.203.492,692,170–458,861–2,233,3092017629
(3)
103.5024.243.4550,323–6,669–43,6542017710
(3)
105.4026.945.45216,229–59,605–156,6242017717
(3)
105.6727.084.1981,874–40,768–41,1062017717
(6)
105.6726.244.19469,677–103,311–366,3662017724
(3)
105.9525.965.652,340–2,340––2017731
(3)
105.5827.255.42158,574–39,000–119,5742017731
(6)
105.5827.005.42476,710–103,4022,236371,072201781
(3)
105.4223.115.58845,000–371,800–473,200201782
(6)
105.5824.175.4583,460–46,59236,868–
?2021
(1)(2)
2021
20211231
201783
(3)
105.455.5119,994–––19,994201787
(3)
105.5626.835.95318,747–204,438–114,309201788
(3)
105.956.0312,649–––12,6492017810
(3)
105.9527.355.5931,356–31,356––2017811
(3)
105.595.46–––––2017817
(3)
105.3927.615.3277,870–59,553–18,3172017825
(3)
105.385.29–––––2017828
(3)
105.2922.885.2834,463–10,296–24,1672017831
(3)
105.3025.675.30–––––2017831
(6)
105.3025.195.30367,744–72,74813,754281,242201795
(3)
105.7823.465.68282,867–12,870–269,9972017912
(3)
105.3925.155.4320,722–6,86413,858–2017913
(3)
105.435.82–––––2017918
(3)
106.2227.316.3726,169–3,900–22,2692017922
(3)
106.5328.366.55187,005–96,850–90,155
?2021
(1)(2)
2021
20211231
2017925
(3)
106.5526.656.56180,869–27,300–153,5692017926
(3)
106.5624.788.7162,751–62,751––2017929
(3)
107.4926.807.96199,992–162,500–37,4922017111
(3)
107.1027.006.84284,310–50,4147,540226,35620171130
(3)
106.3827.286.1536,231–17,2778,19010,764201815
(3)
107.7224.877.58112,788–93,717–19,0712018131
(3)
109.5227.0410.44111,490–27,105–84,3852018228
(3)
1011.6126.9511.0432,604–24,700–7,9042018430
(3)
1013.3726.0113.0438,727–21,320–17,4072018626
(3)
1012.7024.3712.341,584,726–600,28848,477935,9612018629
(3)
1011.9025.5311.8332,214–20,111–12,1032018831
(3)
1013.6725.0013.6621,203–7,462–13,7412018831
(7)
1013.6713.66108,537–––108,5372018928
(3)
1013.2813.2565,433–––65,4332018928
(8)
1013.2813.2539,260–––39,260
?2021
(1)(2)
2021
20211231
20181130
(3)
1011.0727.0811.7943,827–32,799–11,02820181231
(3)
1010.5325.4710.79287,157–110,53932,565144,05320181231
(8)
1010.5326.1010.7947,996–35,269–12,7272019125
(3)
109.6225.2210.4473,021–34,372–38,6492019228
(3)
1010.7729.6310.54222,326–91,572–130,754201935
(3)
1011.6826.8411.5198,735–20,241–78,4942019510
(3)
109.3310.3244,213–––44,213201965
(3)
109.2525.539.234,162,067–850,265237,6403,074,1622019628
(3)
109.6723.269.53155,584–53,41763,45338,7142019830
(3)
1011.1425.2311.06138,476–41,275–97,20120191129
(3)
1015.7115.8339,221–––39,22120191231
(3)
1012.8025.4712.9254,431–24,908–29,523202033
(3)
1012.6226.2712.1936,244–15,587–20,6572020331
(3)
109.6529.639.67404,235–109,460–294,7752020512
(3)
1012.5612.1838,597–––38,597
?2021
(1)(2)
2021
20211231
2020529
(3)
1012.4912.7321,281–––21,2812020617
(3)
1013.3326.0113.422,880,566–453,505206,9212,220,1402020630
(3)
1014.5514.66212,771–––212,771202087
(3)
1017.2416.9940,248–––40,2482020831
(3)
1018.6918.8514,040–––14,0402020930
(3)
1021.6522.038,021–––8,0212020116
(3)
1023.0823.07175,708–––175,70820201130
(3)
1021.9920.9933,319––6,35726,9622021122
(3)
1027.4628.81–64,441––64,4412021226
(3)
1025.3625.81–6,331––6,3312021331
(3)
1025.6126.78–158,834––158,834202157
(3)
1024.1524.78–84,240––84,2402021528
(3)
1027.0027.58–121,485––121,4852021616
(3)
1025.5426.53–2,714,413–380,4582,333,9552021630
(3)
1027.4827.28–88,829––88,829
?2021
(1)(2)
2021
20211231
202186
(3)
1025.8425.61–164,151–5,889158,2622021831
(3)
1023.2223.72–153,322––153,3222021930
(3)
1027.8128.73–61,230––61,2302021115
(3)
1028.3828.08–45,786––45,78620211130
(3)
1026.4026.85–64,649––64,64920211231
(3)
1021.0320.84–59,332––59,332
64,082,5956,244,52414,471,0931,790,95354,065,073
(1) 13
(2) 13
(3) 25%
75%25%36(4)(5)
(6) 20%80%20%48
?2021
(7) 48(8)2016
20216162021420
2021616202111,2503,000AnthonyC.HooperDonald W. GlazerMichael GollerRanjeev KrishanaThomas MalleyCorazon (Corsee) D. Sanders600
255,450
3. 2018
20181172018127201820186620182019652018
202162018
2021912018202112312,160,7692018
201815%20182018
201820185%
?2021
2018
1%10%25,000
319185%
2018
4. 2018
201866201812,000,0002018
20188720182021123120182018
2018831201813.662021123120189,334,659
0.7%202241920189,366,62920224190.7%201819
?2021
20211137,453201820211231
30,9012018
(1)(2)
2021
20211231
2018831
(3)
1013.6725.4913.6637,453–6,552–30,901
37,453–6,552–30,901
(1) 13
(2) 13
(3) 25%
75%25%36
2018
5635(c)(4)2018
?2021
201812,000,00020182018
2018
1%
(i)
1/13(ii)
2018
?2021
2120211215
115,055,260
Thomas MalleyAnthony C. HooperCorazon(Corsee) D. SandersThomas MalleyCorazon (Corsee) D. SandersAnthony C. HooperThomas Malley
20211231
?2021
13.2013.2113.22
2022420
2018882021
20222022323Ernst & Young LLP
20221231
2022420
?2021
20211231
2021
A.2.1202211C.2.1
Ranjeev Krishana
?2021
3.21C.3.3C.3.7
Thomas MalleyCorazon (Corsee) D. SandersAnthony C. HooperThomasMalley3.10(2)3.21
3.25B.1.2
Ranjeev Krishana
A.5.2
Donald W. GlazerMichael GollerAlessandro RivaAnthony C. HooperDonald W. Glazer
?2021
20211231
B.8
Scott A. SamuelsScott A. Samuels
202111
?2021
202111
Anthony C. Hooper
Margaret Han DuganDonald W. GlazerMichael GollerRanjeev KrishanaThomas MalleyCorazon (Corsee) D. SandersAlessandro Riva
2021
3.13
?2021
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2022
?2021
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2021
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3.21
20211231
www.beigene.comHKEX investors2021
202020212021
?2021
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35,000,00085,000,000
?2021
20211231256www.beigene.comHKEXinvestors2021
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Donald W. GlazerMichael GollerAnthony C. HooperAlessandro RivaDonald W. Glazer2021224Anthony C. Hooper2022131
202121Alessandro Riva
?2021
20211231
www.beigene.comHKEX investors2021
2021
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???
20201231256MargaretHan DuganMichael GollerThomas MalleyAlessandro RivaCorazon (Corsee) D.SandersCorazon (Corsee) D. Sanders
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?2021
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20202262021224
20211231
Anthony C. HooperMargaret Han DuganRanjeev KrishanaCorazon(Corsee) D. SandersAnthony C. Hooper www.beigene.comHKEX investors
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www.beigene.comHKEX investors
2021
?2021
(Mourant Governance Services (Cayman) Limited, 94 Solaris Avenue, CamanaBay,Grand Cayman KY1-1108, Cayman Islands(a)(b)
193414a-8(b)(2)(c)(d)(e)(f)(i)(ii)
(g)
D.3.1202211A.2.1
?2021
20211231
(1)
9/91/1Anthony C. Hooper
(3)
9/912/123/35/51/1
9/93/41/1
9/96/75/51/1Donald W. Glazer9/93/31/1Michael Goller9/93/34/41/1Ranjeev Krishana9/97/75/51/1Thomas Malley9/912/124/41/1Corazon (Corsee) D.
Sanders
(2)
9/911/124/43/51/1
(3)(4)
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9/96/74/41/1
(1) 202221Margaret Han DuganAlessandro RivaDugan
Riva2022225Dugan
(2) 2021224Sanders
(3) 2021224Anthony C. Hooper
(4) 2022131
?2021
A.2.7202211C.2.720211231
2021123120211231
?2021
20211231202221Margaret Han DuganAlessandro Riva20221DuganRiva
202120201231
20212020
7,2273,811
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2020
?2021
201910312020
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?
12.5
LUMAKRAS
? (sotorasib)
?2021
LUMAKRAS
? (sotorasib)
14A.52
14A.53(1)14A.5214A.53(1)(a) 14A(b)(c)(d)
14A.5514A.56(e) 2019111
?2021
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?
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?2021
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1,2503,750
(a)(b)(c)
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2021123120211231(a)(b)
(c)
?2021
20203172020924
20.6%
20.4%(i)
(ii)2020121(a)
20%(b)60(c)2023121
20203182020925202010
20219165,5292,151,87750,000
?2021
202092473,640,000500,000,00014,728,000100,000,00058,912,000400,000,000200,000,000(i)2021119
(ii)2021108(i)2022119
(ii)14A15
2021123114A.71
2,069,546
399.43137
2021123127
14A
?2021
Committee of Sponsoring Organizations of the Treadway Commission2013
?2021
?2021
????
(i)(ii)
?2021
20211231
D.2.3
Scott A.Samuels202112313.29
6162
?2021
(MourantGovernance Services (Cayman) Limited, 94 Solaris Avenue, Camana Bay, Grand Cayman KY1-1108,Cayman Islands
(Mourant Governance Services (Cayman) Limited, 94 Solaris Avenue, CamanaBay, Grand Cayman KY1-1108, Cayman Islands[]
2022
2016282021616
2021430(www.hkexnews.hk)
20211215
?2021
1933
?2021
277381
20211231
20211231
?2021
20211231
1,459.220211231
213.9
?
2021
Novartis Pharma AG20211231538.120211231111.9
1)PD-12
650.0
PD-1
PD-1
?2021
?
2021
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2022330
?2021
123120212020
4,375,6781,381,950 4328307 52,241,9623,268,725 6483,11360,403 7242,62689,293 13270,173160,012
7,613,8804,960,690 46,8817,748 10587,605357,686 9117,43190,581 1146,6795,000 12110,42465,962 13163,049113,090
1,032,069640,067
8,645,9495,600,757
14262,400231,957 13558,055346,144 3187,414– 1221,39520,380 921,92513,895 3120,801127,808 15427,565335,015
1,599,5551,075,199
?2021
123120212020
15202,113183,637 3220,289– 943,04129,417 1214,16910,792 3269,561375,040 1354,23457,429
803,407656,3152,402,9621,731,514
0.0001 9,500,000,0002021 20201231 1,334,804,2811,190,821,941133118
11,191,0077,414,9322017,9506,942
(4,966,103)(3,552,749)
6,242,9873,869,2438,645,9495,600,757
?2021
123120212020
16633,987308,874 3542,296– 1,176,283308,874 164,90670,657 1,459,2391,294,877 990,123600,176 11750846 2,615,0181,966,556
(1,438,735)(1,657,682) (15,757)1,998 515,90437,490
(1,438,588)(1,618,194)12(25,234)(17,671)
(1,413,354)(1,600,523)
–(3,617)
(1,413,354)(1,596,906)18(1.17)(1.47)181,206,210,0491,085,131,783
(15.23)(19.13)
92,785,38883,471,676
?2021
123120212020
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?2021
123120212020
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?2021
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?
2021
20191231801,340,698792,925,970(8,001)(1,955,843)962,20516,150978,355
145,838,979142,069,596––2,069,610–2,069,610206,635,013212,162,386––2,162,407–2,162,407
38,020,892393,098––93,101–93,101
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115,055,260123,392,604––3,392,616–3,392,616
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28,778,893392,759––92,762–92,762(2,003,690)–––––––
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?2021
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2021123142
BeiGene 101100%BeiGene AUS Pty Ltd
BeiGene Australia
56,947,230100%
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1100%
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?2021
BeiGene Turkey Medical Products
Trade Limited Company
10,000100%BeiGene Ireland Limited
BeiGene Ireland
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BeiGene NZ, Limited
100,000100%BeiGene Pharmaceuticals GmbH20,000100%
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*7,000,000100%
*1,000,000100%
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*144,000,000100%
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BeiGene Switzerland
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1.
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2.
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2.
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201911842842842-20-2520211231
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201720192021
2018
2020
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202120201231
202120201231
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20211231123
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202120201231
201811606
(i)(ii)(iii)(iv)(v)
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???EUSA Pharma
100%
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606808
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718718
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20211231202120201231483,113,00060,403,000
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300,000,00020201231
38.7%25.4%2020123159.6%
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123120212020484,646–53,671–
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20211
650,000,0001,300,000,000250,000,000
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484,646,000165,354,000
20211231202112312021123153,421,000
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2021
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745,000,0001,150,000,000
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300,000,000
71,980,000213,450,00014,570,000
20211231
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A&R PD-12019614A&R PD-1263,000,00092,050,0002017170,950,00020171213,000,000Celgene Holdings EastCorporationA&R PD-1
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?2021
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606(a)
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20196150,000,000
ABRAXANE
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201910
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2,779,241,0002,162,407,000616,834,000
?2021
3.
20201231
202012312,162,407616,8342,779,241202120201231
123120212020115,464117,005112,486113,986227,950230,991
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3.
20211231791,0592021123120201231
123120212020120,801127,808269,561375,040390,362502,848202120201231
1231202120201,893(1,210)(45,152)(9,750)423(660)(42,836)(11,620)
?2021
3.
202120201231110,303,00038,392,0002021123120201231106,790,000122,828,0002021123118.5%14A14A
202120201231
12312021202083,500109,50015,00015,80043,394–141,894125,300
?2021
3.
Shoreline Biosciences, Inc.20216Shoreline BiosciencesInc.ShorelineShorelineiPSCShorelineShorelineShorelineShoreline2022145,000,000
20211231
202112
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742,000,00020211231
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2021
3.
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202012312021
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503,750,000Assembly20201231
?2021
3.
20208
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?20201020,000,000145,000,00020201231202111
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Seagen, Inc.
201911Seagen, Inc.Seattle Genetics, Inc.
SeagenSeagenSeagenSeagen20,000,000
Seagen
20191231
?2021
3.
Zymeworks Inc.201811ZymeworksZymeworksHER2ZW25(zanidatamab)ZW49Zymeworks
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zanidatamabZW49ZW49zanidatamabZymeworks40,000,000Zymeworks
zanidatamabZW49Azymetric?EFECT?Zymeworks20,000,000Zymeworks
20181231202120201231zanidatamab
?2021
3.
202120201231
4.
20211231202012317,209,0008,055,000
5.
20211231
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5.
20201231
3,267,875850–3,268,7253,267,875850–3,268,7252021123120211231
20211231
Leap Therapeutics, Inc. (Leap)20201Leap5,000,000Leap BB20203LeapLeap20219Leap7,250,000
Leap20211231Leap
8.3%13.1%
2021202012319,386,00012,479,000
?2021
5.
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2021123120201231
123120212020Leap23,80910,810Leap10,3066,669
202112312020123143,722,0009,705,000202120201231
MapKure20196MapKureSpringWorks herapeutics, Inc.SpringWorksBGB-3245MapKureBGB-3245
B-RAFV600BRAFV600B-RAFRAF
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5.
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20211231202012311,176,000491,0002021123120201231MapKure
8,333,0009,509,000
20207
11,782,00080,000,000
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20211231
19.3%
202120201231145,00068,0002021123120201231
12,333,00012,189,000
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5.
202120201231
6.
123120212020483,52860,515
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483,11360,403
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6.
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200,000,000120,000,00080,000,000202010
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2021123115,693,000100,000,000159.
503630
12312021202022,53618,2714,8922,4651,8231,01829,25121,754
?2021
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12312021202060,76241,85056,66948,731117,43190,58121,92513,89543,04129,41764,96643,312
2022123124,2252023123120,0722024123116,103202512318,272202612311,546
70,218(5,252)64,966
?2021
9.
12312021202019,96217,57137,45417,634123120212020
5.15%6.26%
10.
12312021202065,485–118,20378,64050,28837,643144,083111,527119,58596,66927,40420,782525,048345,261(124,286)(73,354)
186,84385,779587,605357,686
?2021
10.
20211175,197,00042
202112312021123120201231
12312021202090,22948,82463,36129,85817,1784,50716,0752,590186,84385,77920212020123144,742,00030,943,000
11.
2021123120201231
2021123120201231
7,500(3,250)4,2507,500(2,500)5,00043,394(965)42,429–––816(816)–816(816)–51,710(5,031)46,6798,316(3,316)5,000
?2021
11.10Merck KGaA
20181231EUSA Pharma
2018920202
20242
123120212020965–7508461,71584620211231123120223,3147504,06420233,3147504,06420243,3147504,06420253,3147504,06420263,3147504,064202725,85950026,359
42,4294,25046,679
?2021
12.
123120212020(606,752)(369,066)34,92333,608(866,759)(1,282,736)(1,438,588)(1,618,194)
123120212020
15,25216,121
(9)(5,678)
8056816,04810,511
7,516(1,152)(47,094)(27,030)
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?2021
12.
123120212020(1,438,588)(1,618,194)
25%25%(359,647)(404,549)185,874218,473(2,826)8,436(27,411)(22,032)
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?2021
12.
123120212020
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20211231
202120201231210,306,000209,085,000
?2021
12.
2021202012313,644,005,0002,230,857,000
2021123120232031942,541,000202520282,325,359,000
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123120212020117,1234,633
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2021123112
202120201231
202112312013202120112021
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12.
2022202112312,863,0000.01
20212020123120211231
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13.
12312021202087,23971,34158,57930,39212,01012,651
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?2021
13.
12312021202010910914,14016,984
(1)24,23729,778
17,16210,913
6,6095,962100,79249,344163,049113,090(1)
123120212020139,966106,765213,922143,30271,56066,13145,66114,37359,63911,87427,3073,699558,055346,144
?2021
13.
12312021202046,35249,139
7,8148,1136817754,23457,429
14.
2021123120201231
1231202120203257,977230,638363,210312611,1101471103860
262,400231,957
?2021
15.
2021123120201231
1231202120202018/04/04580,00092027/04/04(1)1,2558,0003072,0002020/01/22(2)92029/01/20(2)1,56910,000–– 2020/09/24200,000(3)4.5%200,0001,274,535198,3201,294,010 2020/09/24500,000(4)4.5%15,693100,00015,326100,000
(5)209,0481,332,197121,062789,918
427,5652,724,732335,0152,185,9282018/04/04580,00092027/04/04(1)89,444570,00088,584578,0002020/01/22(2)92029/01/20(2)53,353340,00053,641350,0002020/11/09378,00092029/11/08(6)59,316378,00041,412270,206
202,1131,288,000183,6371,198,206
1. 202112314.9%
20211231312,0002,000,000
2. 2020122
1,100,000,000
202012311,100,000,000350,000,000202112314.4%
?2021
15.
3. 120,000,00080,000,000
2021108202110820221092021108198,320,000200,000,000
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(ii)2021108(i) 2022119(ii)
Hillhouse CapitalHillhouse CapitalHillhouse Capital
5. 2021123120201231
1,940,000,00020214192022121520211231206,449,0001,332,197,00020211231
123,122,000789,918,00020211231
4.2%
6. 202112314.3%2021123116,838,000107,794,000
?2021
15.
20211231
20221231427,5652023123115,3002024123131,8322025123138,0272026123142,726
74,228629,678
20212020123129,263,00018,309,0001,054,000338,000
16.
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202120201231
123120212020748,824324,672(114,837)(15,798)633,987308,874
?2021
16.
202120201231
123120212020
?
255,119163,358?
217,98741,702?
70,06547,372
?
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45,9568,496
?
12,515–12,754201633,987308,874202120201231
1231202120201111,8743,198
114,83715,798(67,072)(7,122)123159,63911,874
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20221120211231
2021123157,450,000
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?2021
17.
123120212020164,90670,6571044,74230,943
1,459,2391,294,877 922,53618,271
111,715846
3,8212,642720,551466,962240,712183,481
38,81013,3721,000,073663,815
(67)(1,492)
5,991(4,813)(13,528)(20,352)1069
202120201231463,441,000346,203,000
?2021
18.
123120212020
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(1.17)(1.47)202120201231
2021202012
?2021
19.
201620161201620162016265,029,5952016
201120112016
201120211231201120165,166,5102016201711
(i)(5)%(ii)
20181129,603,6162016201882016
201812201638,553,159
20206201657,200,0002030413201620211231201650,886,939
?2021
19.2018201862018201812,000,000
5635(c)(4)5635(c)(4)20182018
20162018820182021123120189,344,65920182018620183,500,000
201882018123,855,3157,355,3156
15%
10%
?
2021
19.
2018
ADSADS2021831425,386308.3023.72262.0620.168,5752021226436,124236.3018.18200.8615.456,7382020831485,069164.0612.62139.4510.735,2032020228425,425145.5411.20123.719.524,0482019830233,194143.7511.06122.199.402,1922019228154,505137.0510.54116.498.961,385
202112315,194,546
?2021
19.
201120162018
20191231108,417,2543.96 8,999,53613.547.15 (29,707,587)2.82416,509 (2,717,488)7.222020123184,991,7155.27 6,244,52426.4612.40 (17,233,853)4.52367,110 (1,797,498)13.27
2021123172,204,8887.085.811,026,958
2021123155,576,8284.315.08919,118
2021123170,043,2426.795.731,012,9382021123114,466,41488,394,000
2.1
20212020123153,571,00055,127,000
?2021
19.
123120212020
9.94~ 14.974.95~ 11.89
1.1% ~ 1.7%0.6% ~ 1.1%
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0%0%1010
?2021
19.
2016
2019123175,0002.27 –– (75,000)2.27 ––20201231–– –– –– ––
20211231––
20211231––20212020123120211231
?2021
19.
20162018
2019123126,852,26710.72 18,820,58114.20 (7,302,828)10.88 (3,493,048)11.362020123134,876,97212.50 17,173,76725.58 (10,703,381)12.23 (5,264,376)15.822021123136,082,98218.332021123131,392,19418.33
20211231469,862,000
2.6
202120201231
123120212020114,35792,999126,35590,482240,712183,481
?2021
20.
20191231(9,291)1,290–(8,001)
23,4751,073(8,113)16,435
(1)
–(1,492)–(1,492)23,475(419)(8,113)14,9432020123114,184871(8,113)6,942
13,714(4,504)3099,519
(1)
–(67)1,5561,48913,714(4,571)1,86511,0082021123127,898(3,700)(6,248)17,950
(1)
?2021
21.
20212020123120201(ADS)
174.8515,895,00120.5%2,779,241,0002020317(BeiGene, Ltd.)2020
20.6%
20.4%
(i)(ii)
2020121(a)
20%(b)60(c)202312
20207S-3333-238181
(Hillhouse Capital)Baker Bros. Advisors LP145,838,9790.000114.2308
185.002,069,610,000
421,443,00029,614,832
?2021
21.
2019103120191262020924
20219165,5292,151,87750,000,000202112
192.60
391.68115,055,260
3,392,616,000
22.
10%50%
?2021
22.
202120201231
10%
202120201231799,574,000119,776,000
23.
20212020123163,772,00023,717,000401(k)401(k)401(k)
401(k)20214%202120201231
401(k)7,483,0004,840,000
2021202012312,986,0002,960,000
?2021
23.
20212020123134,517,00023,566,00026,703,00015,453,000
20201231
202120201231AXA Pension Solutions AG
20221,604,000
20211231
202244202368202452820252712026197202720313,760
4,868
?2021
24.
20211231168,687,00075,976,000
92,711,000
2021123142,394,000
1,250,000,00020211231791,059,000
2021123127,985,000
15,000,0002021123112,750,000
?2021
24.
(CRO)
25.
383(1)(a)(b)(c)(f)2202120201231
123120212020724560 828786 919637 *18,70316,890 1410
20,46418,32321,18818,883
* 2526
?2021
25.
202120201231
(a)
20212020123120211231
Thomas Malley89––345–434
76––345–421Donald W. Glazer70––345–415Michael Goller73––345–418Ranjeev Krishana76––345–421
84––345–429
72––396–468Corazon (Corsee) D. Sanders92––339–431
632––2,805–3,437
?2021
25.
(a)
20201231
70––290–360Donald W. Glazer63––290–353Michael Goller61––290–351Ranjeev Krishana63––290–353Thomas Malley78––290–368
73––290–363
59––445–504Corazon (Corsee) D. Sanders24––118–142
491––2,303–2,794
?2021
25.
(b)
202120201231
202120201231
123120212020–– 828786 919637 15,55314,376 1410
17,31415,80917,31415,809
?2021
25.
(b)
202120201231Anthony C.Hooper202120201231
20211231
100–1504,704–4,954Anthony C. Hooper92––345–437
192–1505,049–5,39120201231
100–1506,157–6,407Anthony C. Hooper69––211–280
169–1506,368–6,687
?2021
26.
202120201231
20212020
1231202120201,9831,7321,3851,03717,64613,268
323321,04616,070
2021202025,000,00130,000,000–130,000,00135,000,000–135,000,00140,000,0002–60,000,00165,000,000–180,000,00185,000,0001–
?2021
26.
202120201231
27.
202120201231
20211231(i)100,0002020100,000(ii)150,0002020150,000(iii)241,8392020560,599
3,000,00020204,000,000(iv)39,0001,000,0002020
14A
?2021
28.
123120212020517,173290,646495,26518,228163,845–1,176,283308,8742021123120211231
379,607,000
?
115,658,00020201231
?
20211231
?2021
29.
20211231
(i)(iii)(1,459,239)(21,541)–(1,480,780)(990,123)(27,189)–(1,017,312)(1,438,588)(48,730)–(1,487,318)
25,2345,253(56,237)(25,750)(1,413,354)(43,477)(56,237)(1,513,068)(1,413,354)(43,477)(56,237)(1,513,068)
?2021
29.
20201231
(i)(iii)(1,294,877)(5,338)–(1,300,215)
(600,176)(12,280)–(612,456)(1,618,194)(17,618)–(1,635,812)
17,6711,143(41,404)(22,590)(1,600,523)(16,475)(41,404)(1,658,402)(1,596,906)(16,475)(41,404)(1,654,785)
?2021
29.
20211231
(i)(ii)(iii)110,4245,253––125,744
10,067*––8,645,94915,320––8,661,26911,191,00748,730–56,23711,809,005
125,319*307,894*79,818*(4,966,103)(48,730)–(56,237)(5,568,781)
5,253––
(115,252)*(307,894)*(79,818)*6,242,98715,320––6,258,307
?2021
29.
20201231
(i)(ii)(iii)65,9621,143––76,029
8,924*––5,600,75710,067––5,610,8247,414,93217,618–41,4047,927,963
107,701*307,894*38,414*(3,552,749)(17,618)–(41,404)(4,055,713)
1,143––(98,777)*(307,894)*(38,414)*3,869,24310,067––3,879,310
*
?2021
29.
(i)
2021123148,730,000202017,618,000202112315,253,00020201,143,000
125,319,00010,067,00020201231115,252,00020201231202111(ii)
?2021
29.
(ii)
20162307,894,000
307,894,000(iii)
2016-
2021123120201231
2021123156,237,000202041,404,000
2020123179,818,00079,818,000
202111
?2021
29.
(iv)
201911
2021123120211231(v)
2021123120211231
?2021
30.
123120212020
3,715,170332,372 14– 2,044,1982,885,650 920,819512,107
6,680,2013,730,129 169,328138,305 6,5636,087 7,031– 552,032931,899
734,9541,076,291
7,415,1554,806,420
292,988127,478 123,34161,974 120,801127,808 247,076244,298
784,206561,558
?2021
123120212020
269,561375,040 118,401579
387,962375,6191,172,168937,177
0.00019,500,000,000 2021123120201231 1,334,804,2811,190,821,941133118 11,191,0077,414,932 17,9506,942 (4,966,103)(3,552,749)
6,242,9873,869,2437,415,1554,806,420
30.
?2021
30.
20191231801,340,698792,925,970(8,001)(1,955,843)962,205
145,838,979142,069,596––2,069,610206,635,013212,162,386––2,162,407
38,020,892393,098––93,101(1,013,641)1–––1
––183,481––183,481––(19,599)––(19,599)–––14,943–14,943––––(1,596,906)(1,596,906)202012311,190,821,9411187,414,9326,942(3,552,749)3,869,243
115,055,260123,392,604––3,392,616
2,151,877–50,000––50,00028,778,893392,759––92,762(2,003,690)–––––
––240,712––240,712–––11,008–11,008––––(1,413,354)(1,413,354)202112311,334,804,28113311,191,00717,950(4,966,103)6,242,987
?2021
31.
202112312020123132.
2022330
?2021
2011201141520154172011201620161142016
2020428201820181172018127
2018201866
201820216162021912018 2018
2018662018872018ADS13
198747
20191031202012202161620211215
?2021
20101028
2017125201733BeiGene Switzerland GmbH201791BLA
NMPA(CDE)
CMO
CRO
?2021
EMA(European Medicines Agency)
EUSAEUSA PharmaFDA(U.S. Food and Drug Administration)
(General Data Protection Regulation)(EU)2016/679
19981127
GEM
?2021
NMPA(National Medical Products Administration)
Novartis Pharma AG
201873020211231
sBLA
?2021
20191031
sNDA
?2021
BRAFB-rafBTK
BcHLCLL
FcγFcγHCC
MCLMZLNSCLCPARPADPDNA
DNA
?2021
PD-11Tpro-B
PD-L1PD-L2PD-1T
RAFRAFBRAF-BRAF
BRAF-CRAFCRAF-CRAF
SLLTTT
BTIM-3T 3Th1
UCWM